Seid Mohammed Abdu, Akalu Yonas, Gela Yibeltal Yismaw, Belsti Yitayeh, Diress Mengistie, Fekadu Sofonias Addis, Dagnew Baye, Getnet Mihret
Unit of Human Physiology, Department of Biomedical Science, College of Health Sciences, Debre Tabor University, P. O. Box: 272, Debre Tabor, Ethiopia.
Department of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Diabetol Metab Syndr. 2021 Aug 17;13(1):86. doi: 10.1186/s13098-021-00704-w.
Diabetes mellitus is a serious metabolic disorder which becomes common in middle and low incomes countries since few decades. Microvascular complications include retinopathy, neuropathy and nephropathy all of which can lead to disability, dependency, accelerate their morbidity, and mortality. In Ethiopia, there is paucity data regarding this topic. Hence, this study aimed to assess prevalence of microvascular complications and its predictors among type 2 diabetes mellitus patients.
Cross-sectional study was conducted from February to March 2020 at Dessie town hospitals. We used simple random sampling to recruit study participants and pre-tested interviewer administered questionnaire to collect the data. Data was entered into Epi-Data 3.1 and exported to SPSS-23 for analysis. Binary logistic regression was done to select potential variables to be adjusted at p ≤ 0.25. After running multivariable regression, variables with a p-value ≤ 0.05 were declared as statistically significant.
Three hundred and thirty-five type 2 DM patients participated in the study, of which 54.6% were males. One hundred and twenty-seven [37.9% (95% CI 32.5%-43.3%)] of diabetes mellitus had at least one microvascular complications. These were retinopathy 24.8%, nephropathy 16.1%, and neuropathy 8.1%. Age 60-87 years (AOR = 2.76, 95% CI 1.02-7.46), duration of diabetes > 5 years (AOR = 4.09, 95% CI 2.40-6.96), mellitus and co-morbid hypertension (AOR = 3.52, 95% CI 2.09-5.95), were statistically significant.
In this study, diabetic microvascular complications are prevalent. Increasing the age of participants, longer duration of diabetes mellitus and co-morbid hypertension were independent predictors. Health workers should give emphasis for diabetes mellitus through early screening and health education, abrupt medication for aged patients with long duration of diabetes mellitus, and hypertension, and also early detection and management of microvascular complication.
糖尿病是一种严重的代谢紊乱疾病,在过去几十年中,在中低收入国家变得越来越普遍。微血管并发症包括视网膜病变、神经病变和肾病,所有这些都可能导致残疾、依赖,加速发病和死亡。在埃塞俄比亚,关于这个主题的数据很少。因此,本研究旨在评估2型糖尿病患者微血管并发症的患病率及其预测因素。
2020年2月至3月在德西镇医院进行了横断面研究。我们采用简单随机抽样招募研究参与者,并使用预先测试的访谈员管理的问卷收集数据。数据录入Epi-Data 3.1并导出到SPSS-23进行分析。进行二元逻辑回归以选择在p≤0.25时要调整的潜在变量。运行多变量回归后,p值≤0.05的变量被宣布具有统计学意义。
335名2型糖尿病患者参与了研究,其中54.6%为男性。127名[37.9%(95%可信区间32.5%-43.3%)]糖尿病患者至少有一种微血管并发症。这些并发症分别为视网膜病变24.8%、肾病16.1%和神经病变8.1%。年龄60-87岁(调整后比值比=2.76,95%可信区间1.02-7.46)、糖尿病病程>5年(调整后比值比=4.09,95%可信区间2.40-6.96)、糖尿病合并高血压(调整后比值比=3.52,95%可信区间2.09-5.95)具有统计学意义。
在本研究中,糖尿病微血管并发症很普遍。参与者年龄增加、糖尿病病程延长和合并高血压是独立的预测因素。卫生工作者应通过早期筛查和健康教育、对糖尿病病程长的老年患者和高血压患者进行突击药物治疗,以及早期发现和管理微血管并发症,来重视糖尿病。