Department of Microbiology, Government College University, Faisalabad, Pakistan.
Department of Biochemistry, Government College University, Faisalabad, Pakistan.
J Appl Biomater Funct Mater. 2021 Jan-Dec;19:22808000211040304. doi: 10.1177/22808000211040304.
The implants are increasingly being a part of modern medicine in various surgical procedures for functional or cosmetic purposes. The progressive use of implants is associated with increased infectious complications and prevention of such infections always remains precedence in the clinical settings. The preventive approaches include the systemic administration of antimicrobial agents before and after the surgical procedures as well as the local application of antibiotics. The relevant literature and existing clinical practices have highlighted the role of antimicrobial coating approaches in the prevention of implants associated infections, although the applications of these strategies are not yet standardized, and the clinical efficacy is not much clear. The adequate data from the randomized control trials is challenging because of the unavailability of a large sample size although it is compulsory in this context to assess the clinical efficacy of preemptive practices. This review compares the efficacy of preventive approaches and the prospects of antimicrobial-coated implants in preventing implant-related infections.
植入物在各种功能或美容手术中越来越成为现代医学的一部分。植入物的广泛应用与感染并发症的增加有关，而在临床环境中，预防感染始终是首要任务。预防措施包括在手术前后全身性应用抗菌药物以及局部应用抗生素。相关文献和现有临床实践强调了抗菌涂层方法在预防与植入物相关的感染中的作用，尽管这些策略的应用尚未标准化，其临床疗效也不是很明确。尽管在这种情况下评估预防措施的临床疗效是强制性的，但由于缺乏大样本量，很难从随机对照试验中获得足够的数据。本综述比较了预防方法和抗菌涂层植入物在预防与植入物相关感染方面的疗效。
