Department of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, 18057 Rostock, Germany.
Department of Health, University of Witten/Herdecke, Alfred-Herrhausen-Str. 50, 58455 Witten, Germany.
Med Sci (Basel). 2021 Aug 25;9(3):55. doi: 10.3390/medsci9030055.
A large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wound closure, which is a crucial parameter for wound healing. However, vascular supply plays an equally important role and corresponding models for selective or parallel investigation of microcirculation regeneration and angiogenesis are also described. In this review article, we therefore focus on the different levels of investigation of skin wound healing (in vivo to in virtuo) and the investigation of angiogenesis and its parameters.
目前有大量的模型可用于研究皮肤伤口愈合。这些模型可用于研究在生理和病理条件下以特定阶段发生的过程。大多数模型都集中在伤口闭合上，这是伤口愈合的一个关键参数。然而，血管供应也起着同样重要的作用，并且还描述了用于选择性或平行研究微循环再生和血管生成的相应模型。因此，在这篇综述文章中，我们重点介绍了皮肤伤口愈合（从体内到虚拟）以及血管生成及其参数的不同研究水平。
