Fauzi Muhammad Al Rizqi Dharma, Pudjiastuti Pratiwi, Wibowo Arief Cahyo, Hendradi Esti
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia.
Faculty of Advanced Technology and Multidiscipline, Universitas Airlangga, Surabaya 60115, Indonesia.
Polymers (Basel). 2021 Aug 10;13(16):2666. doi: 10.3390/polym13162666.
Intense efforts to develop alternative materials for gelatine as a drug-delivery system are progressing at a high rate. Some of the materials developed are hard capsules made from alginate, carrageenan, hypromellose and cellulose. However, there are still some disadvantages that must be minimised or eliminated for future use in drug-delivery systems. This review attempts to review the preparation and potential of seaweed-based, specifically carrageenan, hard capsules, summarise their properties and highlight their potential as an optional main component of hard capsules in a drug-delivery system. The characterisation methods reviewed were dimensional analysis, water and ash content, microbial activity, viscosity analysis, mechanical analysis, scanning electron microscopy, swelling degree analysis, gel permeation chromatography, Fourier-transform infrared spectroscopy and thermal analysis. The release kinetics of the capsule is highlighted as well. This review is expected to provide insights for new researchers developing innovative products from carrageenan-based hard capsules, which will support the development goals of the industry.
为开发替代明胶作为药物递送系统的材料，目前正在大力推进且进展迅速。已开发出的一些材料包括由藻酸盐、卡拉胶、羟丙甲纤维素和纤维素制成的硬胶囊。然而，仍存在一些缺点，必须将其最小化或消除，以便未来用于药物递送系统。本综述试图回顾基于海藻的硬胶囊，特别是卡拉胶硬胶囊的制备方法和潜力，总结其特性，并强调其作为药物递送系统中硬胶囊可选主要成分的潜力。所回顾的表征方法包括尺寸分析、水分和灰分含量、微生物活性、粘度分析、力学分析、扫描电子显微镜、溶胀度分析、凝胶渗透色谱、傅里叶变换红外光谱和热分析。还突出了胶囊的释放动力学。预计本综述将为利用基于卡拉胶的硬胶囊开发创新产品的新研究人员提供见解，这将支持该行业的发展目标。
