Gheorghita Roxana, Anchidin-Norocel Liliana, Filip Roxana, Dimian Mihai, Covasa Mihai
Department of Health and Human Development, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.
Integrated Center for Research, Development and Innovation in Advanced Materials, Nanotechnologies, and Distributed Systems for Fabrication and Control, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.
Polymers (Basel). 2021 Aug 15;13(16):2729. doi: 10.3390/polym13162729.
Research regarding the use of biopolymers has been of great interest to scientists, the medical community, and the industry especially in recent years. Initially used for food applications, the special properties extended their use to the pharmaceutical and medical industries. The practical applications of natural drug encapsulation materials have emerged as a result of the benefits of the use of biopolymers as edible coatings and films in the food industry. This review highlights the use of polysaccharides in the pharmaceutical industries and as encapsulation materials for controlled drug delivery systems including probiotics, focusing on their development, various applications, and benefits. The paper provides evidence in support of research studying the use of biopolymers in the development of new drug delivery systems, explores the challenges and limitations in integrating polymer-derived materials with product delivery optimization, and examines the host biological/metabolic parameters that can be used in the development of new applications.
近年来，关于生物聚合物用途的研究尤其引起了科学家、医学界和工业界的极大兴趣。生物聚合物最初用于食品领域，因其特殊性能，其应用范围扩展到了制药和医疗行业。由于生物聚合物在食品工业中用作可食用涂层和薄膜具有诸多益处，天然药物包封材料的实际应用应运而生。本综述重点介绍了多糖在制药行业中的应用，以及作为包括益生菌在内的控释药物递送系统的包封材料，着重阐述了其发展、各种应用及优势。本文为研究生物聚合物在新型药物递送系统开发中的应用提供了证据支持，探讨了将聚合物衍生材料与产品递送优化相结合时所面临的挑战和限制，并研究了可用于开发新应用的宿主生物学/代谢参数。
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