Centre for Global Health Research, Unity Health Toronto and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Department of Public Health and Mortality Studies, International Institute for Population Sciences, Mumbai, India.
BJOG. 2022 Mar;129(4):550-561. doi: 10.1111/1471-0528.16888. Epub 2021 Sep 15.
To assess national and regional trends and causes-specific distribution of maternal mortality in India.
Nationally representative cross-sectional surveys.
All of India from 1997 to 2020.
About 10 000 maternal deaths among 4.3 million live births over two decades.
We analysed trends in the maternal mortality ratio (MMR) from 1997 through 2020, estimated absolute maternal deaths and examined the causes of maternal death using nationally representative data sources. We partitioned female deaths (aged 15-49 years) and live birth totals, based on the 2001-2014 Million Death Study to United Nations (UN) demographic totals for the country.
Maternal mortality burden and distribution of causes.
The MMR declined in India by about 70% from 398/100 000 live births (95% CI 378-417) in 1997-98 to 99/100 000 (90-108) in 2020. About 1.30 million (95% CI 1.26-1.35 million) maternal deaths occurred between 1997 and 2020, with about 23 800 (95% CI 21 700-26 000) in 2020, with most occurring in poorer states (63%) and among women aged 20-29 years (58%). The MMRs for Assam (215), Uttar Pradesh/Uttarakhand (192) and Madhya Pradesh/Chhattisgarh (170) were highest, surpassing India's 2016-2018 estimate of 113 (95% CI 103-123). After adjustment for education and other variables, the risks of maternal death were highest in rural and tribal areas of north-eastern and northern states. The leading causes of maternal death were obstetric haemorrhage (47%; higher in poorer states), pregnancy-related infection (12%) and hypertensive disorders of pregnancy (7%).
India could achieve the UN 2030 MMR goals if the average rate of reduction is maintained. However, without further intervention, the poorer states will not.
We estimated that 1.3 million Indian women died from maternal causes over the last two decades. Although maternal mortality rates have fallen by 70% overall, the poorer states lag behind.
评估印度的全国和地区趋势以及孕产妇死亡的病因分布。
具有全国代表性的横断面调查。
印度,1997 年至 2020 年。
20 年间约有 430 万活产中发生了 10000 例孕产妇死亡。
我们分析了 1997 年至 2020 年期间孕产妇死亡率(MMR)的趋势,估计了绝对孕产妇死亡人数,并使用具有全国代表性的数据源检查了孕产妇死亡的病因。我们根据 2001-2014 年百万死亡研究和该国的联合国(UN)人口总数,对女性死亡(年龄在 15-49 岁之间)和活产总数进行了划分。
孕产妇死亡负担和病因分布。
印度的 MMR 从 1997-98 年的 398/100000 活产(95%CI 378-417)下降到 2020 年的 99/100000(90-108),降幅约为 70%。1997 年至 2020 年间约有 130 万(95%CI 126-135 万)例孕产妇死亡,2020 年约有 23800 例(95%CI 21700-26000 例),其中大多数发生在较贫困的州(63%)和 20-29 岁的妇女(58%)。阿萨姆邦(215)、北方邦/北阿坎德邦(192)和中央邦/恰蒂斯加尔邦(170)的 MMR 最高,超过了印度 2016-2018 年估计的 113(95%CI 103-123)。在调整了教育和其他变量后,东北部和北部各州农村和部落地区的孕产妇死亡风险最高。孕产妇死亡的主要原因是产科出血(47%;在较贫困的州更高)、妊娠相关感染(12%)和妊娠高血压疾病(7%)。
如果保持平均下降速度,印度可以实现联合国 2030 年的 MMR 目标。然而,如果不进一步干预,较贫困的州将无法实现这一目标。
我们估计,在过去的二十年中,有 130 万印度妇女死于孕产妇原因。尽管孕产妇死亡率总体上下降了 70%,但较贫困的州却落后了。