Ackun-Farmmer Marian A, Overby Clyde T, Haws Brittany E, Choe Regine, Benoit Danielle S W
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA.
Curr Opin Biomed Eng. 2021 Sep;19. doi: 10.1016/j.cobme.2021.100308. Epub 2021 Jun 8.
Despite widespread use of conventional diagnostic methods in orthopaedic applications, limitations still exist in detection and diagnosing many pathologies especially at early stages when intervention is most critical. The use of biomaterials to develop diagnostics and theranostics, including nanoparticles and scaffolds for systemic or local applications, has significant promise to address these shortcomings and enable successful clinical translation. These developments in both modular and holistic design of diagnostic and theranostic biomaterials may improve patient treatments for myriad orthopaedic applications ranging from cancer to fractures to infection.
尽管传统诊断方法在骨科应用中广泛使用，但在检测和诊断许多病症方面仍存在局限性，尤其是在干预最为关键的早期阶段。使用生物材料来开发诊断和治疗诊断学，包括用于全身或局部应用的纳米颗粒和支架，对于解决这些缺点并实现成功的临床转化具有重大前景。诊断和治疗诊断学生物材料在模块化和整体设计方面的这些进展，可能会改善从癌症到骨折再到感染等无数骨科应用的患者治疗效果。
