核小体组蛋白的合成性高乙酰化。
Synthetic hyperacetylation of nucleosomal histones.
作者信息
Kajino Hidetoshi, Nagatani Tomomi, Oi Miku, Kujirai Tomoya, Kurumizaka Hitoshi, Nishiyama Atsuya, Nakanishi Makoto, Yamatsugu Kenzo, Kawashima Shigehiro A, Kanai Motomu
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan
Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo 4-6-1 Shiroganedai Minato-ku Tokyo 108-8639 Japan.
出版信息
RSC Chem Biol. 2020 May 19;1(2):56-59. doi: 10.1039/d0cb00029a. eCollection 2020 Jun 1.
We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to sperm chromatin.
我们报道了一种基于4-二甲氨基吡啶（DMAP）的催化剂与具有最佳电子密度的乙酸苯酯的组合，作为一种用于高产率、选择性合成组蛋白赖氨酸残基乙酰化的新化学体系。通过将该化学体系应用于精子染色质，证明了其作为一种独特生物学工具的实用性。
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