College of Fisheries and Life Science, Dalian Ocean University, 52 Heishijiao Street, DalianLiaoning, 116023, China.
College of Marine Technology and Environment, Dalian Ocean University, Dalian, 116023, China.
Fish Physiol Biochem. 2021 Oct;47(5):1669-1685. doi: 10.1007/s10695-021-01008-6. Epub 2021 Aug 30.
Hypoxia in water that caused by reduced levels of oxygen occurred frequently, due to the complex aquatic environment. Hypoxia tolerance for fish depends on a complete set of coping mechanisms such as oxygen perception and gene-protein interaction regulation. The present study examined the short-term effects of hypoxia on the brain in Takifugu rubripes. We sequenced the transcriptomes of the brain in T. rubripes to study their response mechanism to acute hypoxia. A total of 167 genes were differentially expressed in the brain of T. rubripes after exposed to acute hypoxia. Gene ontology and KEGG enrichment analysis indicated that hypoxia could cause metabolic and neurological changes, showing the clues of their adaptation to acute hypoxia. As the most complex and important organ, the brain of T. rubripes might be able to create a self-protection mechanism to resist or reduce damage caused by acute hypoxia stress.
由于复杂的水生环境，水中氧气水平降低导致的缺氧现象经常发生。鱼类的耐缺氧能力取决于一整套应对机制，如氧气感知和基因-蛋白质相互作用的调节。本研究检测了短期缺氧对红鳍东方鲀大脑的影响。我们对红鳍东方鲀大脑的转录组进行了测序，以研究其对急性缺氧的反应机制。在暴露于急性缺氧后，红鳍东方鲀大脑中有 167 个基因表达发生差异。基因本体论和 KEGG 富集分析表明，缺氧可能导致代谢和神经变化，显示了它们对急性缺氧适应的线索。作为最复杂和重要的器官，红鳍东方鲀的大脑可能能够创造一种自我保护机制，以抵抗或减少急性缺氧应激造成的损害。
