Department of Ophthalmology, Gangneung Asan Hospital, Gangneung, Korea.
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):38. doi: 10.1167/iovs.62.10.38.
The purpose of this study was to investigate the relationship between refractive error and ocular biometry and its implication in the pathogenesis of primary angle closure (PAC).
We have retrospectively recruited 119 PAC eyes and 388 non-PAC eyes with an axial length (AL) of ≤25.0 mm and a spherical equivalent (SE) of ≥-6.0 diopters (D). Stepwise multiple regression was performed for keratometry value (K), AL, anterior chamber depth (ACD), and SE.
PAC eyes were more likely to be in women and have a higher IOP and shorter AL than non-PAC eyes. In a multiple regression analysis, SE was not associated with PAC. The associations between AL and SE or AL and ACD were not different in PAC eyes compared with non-PAC eyes. However, the cornea was flatter in PAC eyes (β = -0.448, P < 0.001), and a flatter cornea was associated with more hyperopic refraction (β = -0.454, P < 0.001) and shallower ACD (β = 0.073, P < 0.001) in PAC eyes. ACD was not associated with SE in non-PAC eyes, but shallower ACD was associated with greater myopic refraction in PAC eyes (β = 1.117, P = 0.006).
PAC eyes seem to have flatter cornea compared with non-PAC eyes. A shallower ACD seems to be associated with greater myopic refraction in PAC eyes, but not in non-PAC eyes.
本研究旨在探讨屈光不正与眼球生物测量之间的关系及其在原发性闭角型青光眼（PAC）发病机制中的意义。
我们回顾性招募了 119 只 PAC 眼和 388 只非 PAC 眼，这些眼的眼轴长度（AL）≤25.0mm，等效球镜（SE）≥-6.0 屈光度（D）。采用逐步多元回归分析角膜曲率值（K）、AL、前房深度（ACD）和 SE。
PAC 眼女性比例较高，眼压（IOP）较高，眼轴较短。多元回归分析显示，SE 与 PAC 无关。与非 PAC 眼相比，PAC 眼中 AL 与 SE 或 AL 与 ACD 的关系没有差异。然而，PAC 眼中的角膜更平坦（β=-0.448，P<0.001），更平坦的角膜与更远视的屈光度（β=-0.454，P<0.001）和更浅的 ACD（β=0.073，P<0.001）相关。非 PAC 眼中 ACD 与 SE 无关，但在 PAC 眼中，较浅的 ACD 与更大的近视屈光度相关（β=1.117，P=0.006）。
与非 PAC 眼相比，PAC 眼的角膜似乎更平坦。在 PAC 眼中，较浅的 ACD 似乎与更大的近视屈光度相关，但在非 PAC 眼中则不相关。
