Rezaeizadeh Hossein, Rahimi Roja, Abbasi Maryam
Department of Traditional Iranian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Galen Med J. 2019 May 9;8:e1139. doi: 10.31661/gmj.v8i0.1139. eCollection 2019.
Fatigue is one of the most debilitating symptoms of multiple sclerosis (MS), and its definite pathophysiology is unclear. Studies have suggested some correlates for it including dysfunction or atrophy in different parts of the brain. This narrative review study compares the viewpoint of conventional medicine and Persian medicine (PM) about fatigue due to MS and introduces the treatments used for this complaint in PM with an evidence-based approach. PM scholars have used the term equal to fatigue and stated that might be due to exertion or not, while the latter (spontaneous ) can be prodromal of a disease. This pathologic fatigue can be seen in a wide variety of neurologic diseases, though it is the most common in MS patients. Fatigue in MS can be considered one of the equivalents of spontaneous . According to PM texts, neurotonic herbs like , , , , and may be beneficial in alleviating fatigue by brain reinforcement. Different pharmacological mechanisms have been introduced for these plants including antioxidant and/or anti-inflammatory activities. The medicinal plants can be assumed as a valuable source for discovering new medicines for fatigue in MS. Designing preclinical and clinical studies evaluating the effects of mentioned medicinal herbs in fatigue is proposed for obtaining more conclusive results.
疲劳是多发性硬化症（MS）最使人衰弱的症状之一，其确切的病理生理学尚不清楚。研究表明，疲劳与一些因素相关，包括大脑不同部位的功能障碍或萎缩。本叙述性综述研究比较了传统医学和波斯医学（PM）对MS所致疲劳的观点，并以循证医学的方法介绍了波斯医学针对该症状所采用的治疗方法。波斯医学学者使用了与疲劳等同的术语，并指出疲劳可能由劳累引起，也可能并非如此，而后者（自发性疲劳）可能是疾病的前驱症状。这种病理性疲劳可见于多种神经系统疾病，不过在MS患者中最为常见。MS中的疲劳可被视为自发性疲劳的等效症状之一。根据波斯医学文献，诸如[具体草药名称1]、[具体草药名称2]、[具体草药名称3]、[具体草药名称4]和[具体草药名称5]等滋补神经的草药可能有助于通过增强大脑功能来缓解疲劳。已针对这些植物引入了不同的药理机制，包括抗氧化和/或抗炎活性。药用植物可被视为发现治疗MS疲劳新药的宝贵资源。建议设计临床前和临床研究来评估上述草药对疲劳的影响，以获得更具结论性的结果。
