Luo Yinzhou, Qiu Guanzhen, Liu Yize, Li Shanshan, Xu Yeqiu, Zhang Yuanzhuang, Cao Yuan, Wang Yong
Fourth Department of Orthopedic Surgery, Central Hospital Affiliated to Shenyang Medical College, 110024, Shenyang, Liaoning, P.R. China.
Department of Respiratory, Central Hospital Affiliated to Shenyang Medical College, 110024, Shenyang, Liaoning, P.R. China.
Cell Death Discov. 2021 Sep 4;7(1):231. doi: 10.1038/s41420-021-00624-8.
Osteoporosis, which is caused by an imbalance in osteoblasts and osteoclasts, is a global age-related metabolic disease. Osteoblasts induce osteocyte and bone matrix formation, while osteoclasts play an important role in bone resorption. Maintaining a balance between osteoblast formation and osteoclastic absorption is crucial for bone remodeling. Circular RNAs (circRNAs), which are characterized by closed-loop structures, are a class of novel endogenous transcripts with limited protein-coding abilities. Accumulating evidence indicates that circRNAs play important roles in various bone diseases, such as osteosarcoma, osteoarthritis, osteonecrosis, and osteoporosis. Recent studies have shown that circRNAs regulate osteoblast and osteoclast differentiation and may be potential biomarkers for osteoporosis. In the current review, we summarize the expression, function, and working mechanisms of circRNAs involved in osteoblasts, osteoclast differentiation, and osteoporosis.
骨质疏松症是一种全球性的与年龄相关的代谢性疾病，由成骨细胞和破骨细胞失衡引起。成骨细胞诱导骨细胞和骨基质形成，而破骨细胞在骨吸收中起重要作用。维持成骨细胞形成和破骨细胞吸收之间的平衡对于骨重塑至关重要。环状RNA（circRNA）具有闭环结构，是一类蛋白质编码能力有限的新型内源性转录本。越来越多的证据表明，circRNA在各种骨疾病中发挥重要作用，如骨肉瘤、骨关节炎、骨坏死和骨质疏松症。最近的研究表明，circRNA调节成骨细胞和破骨细胞分化，可能是骨质疏松症的潜在生物标志物。在本综述中，我们总结了参与成骨细胞、破骨细胞分化和骨质疏松症的circRNA的表达、功能和作用机制。
