Patil Suryaji, Dang Kai, Zhao Xin, Gao Yongguang, Qian Airong
Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi'an, China.
Front Genet. 2020 Nov 13;11:584118. doi: 10.3389/fgene.2020.584118. eCollection 2020.
Bone is a mechanosensitive organ that provides strength and support. Many bone cells, various pathways, and signaling molecules coordinate bone metabolism and also determine the course of bone diseases, such as osteoporosis, osteonecrosis, osteopenia, etc. Osteoporosis is caused by increased bone resorption and reduced bone formation due to the changes in the level of different proteins and RNAs in osteoclast or/and osteoblasts. The available therapeutic interventions can significantly reduce bone resorption or enhance bone formation, but their prolonged use has deleterious side effects. Therefore, the use of non-coding RNAs as therapeutics has emerged as an interesting field of research. Despite advancements in the molecular field, not much is known about the role of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in bone homeostasis and osteoporosis. Therefore, in this article, we summarize the role of lncRNAs and circRNAs in different bone cells and osteoporosis so that it might help in the development of osteoporotic therapeutics.
骨骼是一种机械敏感器官，提供强度和支撑。许多骨细胞、各种途径和信号分子协调骨骼代谢，也决定骨骼疾病的进程，如骨质疏松症、骨坏死、骨质减少等。骨质疏松症是由于破骨细胞或/和成骨细胞中不同蛋白质和RNA水平的变化导致骨吸收增加和骨形成减少所致。现有的治疗干预措施可以显著减少骨吸收或增强骨形成，但其长期使用会产生有害的副作用。因此，使用非编码RNA作为治疗方法已成为一个有趣的研究领域。尽管分子领域取得了进展，但关于长链非编码RNA（lncRNA）和环状RNA（circRNA）在骨骼稳态和骨质疏松症中的作用仍知之甚少。因此，在本文中，我们总结了lncRNA和circRNA在不同骨细胞和骨质疏松症中的作用，希望有助于骨质疏松症治疗方法的开发。
