Shanti Aya, Hallfors Nicholas, Petroianu Georg A, Planelles Lourdes, Stefanini Cesare
Healthcare Engineering Innovation Center, Biomedical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Front Pharmacol. 2021 Aug 16;12:711307. doi: 10.3389/fphar.2021.711307. eCollection 2021.
Organs-on-chip are gaining increasing attention as promising platforms for drug screening and testing applications. However, lymph nodes-on-chip options remain limited although the lymph node is one of the main determinants of the immunotoxicity of newly developed pharmacological drugs. In this review, we describe existing biomimetic lymph nodes-on-chip, their design, and their physiological relevance to pharmacology and shed the light on future directions associated with lymph node-on-chip design and implementation in drug discovery and development.
芯片器官作为药物筛选和测试应用的有前景平台正受到越来越多的关注。然而，尽管淋巴结是新开发的药理药物免疫毒性的主要决定因素之一，但芯片上淋巴结的选择仍然有限。在这篇综述中，我们描述了现有的仿生芯片上淋巴结、它们的设计以及它们与药理学的生理相关性，并阐明了与芯片上淋巴结设计以及在药物发现和开发中的应用相关的未来方向。
