State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, China.
Nanoscale. 2021 Sep 23;13(36):15142-15150. doi: 10.1039/d1nr04992e.
Pathological stimuli-responsive self-assembly of peptide nanofibers enables selective accumulation of imaging agent cargos in the stimuli-rich regions of interest. It provides enhanced imaging signals, biocompatibility, and tumor/disease accessibility and retention, thereby promoting smart, precise, and sensitive tumor/disease imaging both and . Considering the remarkable significance and recent encouraging breakthroughs of self-assembled peptide nanofibers in tumor/disease diagnosis, this reivew is herein proposed. We emphasize the recent advances particularly in the past three years, and provide an outlook in this field.
病理刺激响应性肽纳米纤维自组装能够选择性地将成像剂有效负载积累在刺激丰富的感兴趣区域。这提供了增强的成像信号、生物相容性以及肿瘤/疾病的可及性和保留性，从而促进了智能、精准和敏感的肿瘤/疾病成像。鉴于自组装肽纳米纤维在肿瘤/疾病诊断中的显著意义和最近令人鼓舞的突破，我们提出了这篇综述。我们强调了特别是在过去三年中的最新进展，并对该领域进行了展望。
