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白藜芦醇的化学预防作用：抑制 p53-A 分子靶向方法。

Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach.

机构信息

Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh.

Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Korea.

出版信息

Molecules. 2021 Sep 2;26(17):5325. doi: 10.3390/molecules26175325.

DOI:10.3390/molecules26175325
PMID:34500758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8433711/
Abstract

Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer that researchers are extremely focused on. Among these studies on natural active substances, one can distinguish the emphasis on resveratrol and its properties, especially the potential anticancer role. Resveratrol is a natural product proven for its therapeutic activity, with remarkable anti-inflammatory properties. Various other benefits/actions have also been reported, such as cardioprotective, anti-ageing, antioxidant, etc. and its rapid digestion/absorption as well. This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. The most recent information regarding the healing action of resveratrol is presented and concentrated to create an updated database focused on this topic presented above.

摘要

大量的实验、临床和流行病学证据已经解释和证明，天然产物在预防和/或改善各种疾病方面非常重要，包括研究人员极为关注的不同类型的癌症。在这些对天然活性物质的研究中，可以区分出对白藜芦醇及其特性的重视，特别是其潜在的抗癌作用。白藜芦醇是一种已被证明具有治疗活性的天然产物，具有显著的抗炎特性。还报道了其他各种益处/作用，如心脏保护、抗老化、抗氧化等，以及其快速消化/吸收。本综述旨在收集和介绍最新发表的关于白藜芦醇及其对癌症预防、分子信号（特别是 p53 蛋白参与）的影响及其治疗前景的研究。提供了有关白藜芦醇治疗作用的最新信息，并集中精力创建一个更新的数据库，重点关注上述主题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/9e147a0defa6/molecules-26-05325-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/44771068d5e5/molecules-26-05325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/12d76575c9d1/molecules-26-05325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/c4e5bfd2f771/molecules-26-05325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/9e147a0defa6/molecules-26-05325-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/44771068d5e5/molecules-26-05325-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/12d76575c9d1/molecules-26-05325-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/c4e5bfd2f771/molecules-26-05325-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9df/8433711/9e147a0defa6/molecules-26-05325-g004.jpg

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