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癌细胞中的多药耐药性：聚焦于应对结肠癌细胞的可能策略计划。

Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells.

作者信息

Karthika Chenmala, Sureshkumar Raman, Zehravi Mehrukh, Akter Rokeya, Ali Faraat, Ramproshad Sarker, Mondal Banani, Kundu Milton Kumar, Dey Abhijit, Rahman Md Habibur, Antonescu Angela, Cavalu Simona

机构信息

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643001, India.

Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University, Alkharj 11942, Saudi Arabia.

出版信息

Life (Basel). 2022 May 30;12(6):811. doi: 10.3390/life12060811.

DOI:10.3390/life12060811
PMID:35743842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9224881/
Abstract

Even though various treatment methods are available for cancer, the death curve is not reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading reasons for treatment failure and lower survival rates. In this review article, we summarize the possible pitfalls during cancer treatment in general, which mainly include multidrug resistance, and propose a hypothesis for colorectal cancer specifically. We also evaluate multidrug resistance in cancer in general and colorectal cancer in particular and hypothesize a concept based on combination therapy with 5-fluorouracil, curcumin, and lipids for the possible management of colorectal cancer. In addition, a hypothetical approach, combining a synthetic agent and a natural chemotherapeutic agent, to treating colorectal cancer is also discussed. This hypothesis could improve the management of colorectal cancer.

摘要

尽管针对癌症有多种治疗方法，但死亡曲线并未下降。癌症四期诊断和耐药性是治疗失败及生存率降低的主要原因。在这篇综述文章中，我们总结了癌症治疗过程中可能存在的陷阱，主要包括多药耐药性，并特别针对结直肠癌提出了一个假设。我们还对癌症总体尤其是结直肠癌中的多药耐药性进行了评估，并基于5-氟尿嘧啶、姜黄素和脂质联合治疗提出了一个概念，用于结直肠癌的可能治疗。此外，还讨论了一种将合成药物与天然化疗药物相结合治疗结直肠癌的假设方法。这一假设可能会改善结直肠癌的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/9a7b2524b676/life-12-00811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/79f71a548a5e/life-12-00811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/5e8a0a805390/life-12-00811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/9a7b2524b676/life-12-00811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/79f71a548a5e/life-12-00811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/5e8a0a805390/life-12-00811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a9/9224881/9a7b2524b676/life-12-00811-g003.jpg

相似文献

[1]
Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells.

Life (Basel). 2022-5-30

[2]
Can curcumin along with chemotherapeutic drug and lipid provide an effective treatment of metastatic colon cancer and alter multidrug resistance?

Med Hypotheses. 2019-7-24

[3]
Multiple strategies with the synergistic approach for addressing colorectal cancer.

Biomed Pharmacother. 2021-8

[4]
Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.

Chin J Integr Med. 2018-11-27

[5]
Effect of curcumin on human colon cancer multidrug resistance in vitro and in vivo.

Clinics (Sao Paulo). 2013-5

[6]
Overview of resistance to systemic therapy in patients with breast cancer.

Adv Exp Med Biol. 2007

[7]
Curcumin as a great contributor for the treatment and mitigation of colorectal cancer.

Exp Gerontol. 2021-9

[8]
[Adjuvant and palliative anticancer treatment of colon carcinoma in 2004].

Praxis (Bern 1994). 2004-9-29

[9]
Modulation of multidrug resistance by andrographolid in a HCT-8/5-FU multidrug-resistant colorectal cancer cell line.

Chin J Dig Dis. 2005

[10]
Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.

Br J Cancer. 2002-5-20

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[2]
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Discov Oncol. 2025-4-9

[3]
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Int J Mol Sci. 2025-2-25

[4]
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Molecules. 2024-8-9

[5]
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Int J Nanomedicine. 2024-8-2

[6]
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Cancer Cell Int. 2024-5-7

[7]
Mutation of PTEN: Loss and Likelihood of Being a Non-responder to Trastuzumab in a Sample of Iraqi Her2+ Breast Cancer Patients.

Cureus. 2024-2-23

[8]
Cinobufotalin regulates the USP36/c-Myc axis to suppress malignant phenotypes of colon cancer cells and .

Aging (Albany NY). 2024-3-15

[9]
Laherradurin Inhibits Tumor Growth in an Azoxymethane/Dextran Sulfate Sodium Colorectal Cancer Model In Vivo.

Cancers (Basel). 2024-1-29

[10]
Tectorigenin Inhibits Glycolysis-induced Cell Growth and Proliferation by Modulating LncRNA CCAT2/miR-145 Pathway in Colorectal Cancer.

Curr Cancer Drug Targets. 2024

本文引用的文献

[1]
Drug-adapted cancer cell lines as preclinical models of acquired resistance.

Cancer Drug Resist. 2019-9-19

[2]
5-fluorouracil and curcumin with pectin coating as a treatment regimen for titanium dioxide with dimethylhydrazine-induced colon cancer model.

Environ Sci Pollut Res Int. 2022-9

[3]
Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint.

Molecules. 2022-3-27

[4]
Risk factors for the recurrence of stage II perforated colorectal cancer: A retrospective observational study.

Asian J Surg. 2023-1

[5]
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review.

Molecules. 2022-3-6

[6]
Multicancer early detection test: Preclinical, translational, and clinical evidence-generation plan and provocative questions.

Cancer. 2022-2-15

[7]
A comprehensive framework for early-onset colorectal cancer research.

Lancet Oncol. 2022-3

[8]
The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors.

Cancer Drug Resist. 2021

[9]
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition.

Drug Resist Updat. 2021-12

[10]
Impact of cancer metabolism on therapy resistance - Clinical implications.

Drug Resist Updat. 2021-12

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