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用于组织工程潜在应用的基于多孔、导电壳聚糖 - 明胶 - 琼脂的聚（3,4 - 乙撑二氧噻吩）：聚苯乙烯磺酸盐支架的合成与表征

Synthesis and Characterization of Porous, Electro-Conductive Chitosan-Gelatin-Agar-Based PEDOT: PSS Scaffolds for Potential Use in Tissue Engineering.

作者信息

Ahmad Ruzaidi Dania Adila, Mahat Mohd Muzamir, Mohamed Sofian Zarif, Nor Hashim Nikman Adli, Osman Hazwanee, Nawawi Mohd Azizi, Ramli Rosmamuhamadani, Jantan Khairil Anuar, Aizamddin Muhammad Faiz, Azman Hazeeq Hazwan, Robin Chang Yee Hui, Hamzah Hairul Hisham

机构信息

Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam 40450, Malaysia.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

Polymers (Basel). 2021 Aug 28;13(17):2901. doi: 10.3390/polym13172901.

DOI:10.3390/polym13172901
PMID:34502941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8434095/
Abstract

Herein we report the synthesis and characterization of electro-conductive chitosan-gelatin-agar (Cs-Gel-Agar) based PEDOT: PSS hydrogels for tissue engineering. Cs-Gel-Agar porous hydrogels with 0-2.0% (/) PEDOT: PSS were fabricated using a thermal reverse casting method where low melting agarose served as the pore template. Sample characterizations were performed by means of scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction analysis (XRD) and electrochemical impedance spectroscopy (EIS). Our results showed enhanced electrical conductivity of the cs-gel-agar hydrogels when mixed with DMSO-doped PEDOT: PSS wherein the optimum mixing ratio was observed at 1% (/) with a conductivity value of 3.35 × 10 S cm. However, increasing the PEDOT: PSS content up to 1.5 % (/) resulted in reduced conductivity to 3.28 × 10 S cm. We conducted in vitro stability tests on the porous hydrogels using phosphate-buffered saline (PBS) solution and investigated the hydrogels' performances through physical observations and ATR-FTIR characterization. The present study provides promising preliminary data on the potential use of Cs-Gel-Agar-based PEDOT: PSS hydrogel for tissue engineering, and these, hence, warrant further investigation to assess their capability as biocompatible scaffolds.

摘要

在此，我们报告了用于组织工程的基于导电壳聚糖 - 明胶 - 琼脂（Cs - Gel - Agar）的聚（3,4 - 乙撑二氧噻吩）：聚苯乙烯磺酸盐（PEDOT：PSS）水凝胶的合成与表征。使用热反向浇铸法制备了含0 - 2.0%（/）PEDOT：PSS的Cs - Gel - Agar多孔水凝胶，其中低熔点琼脂糖作为孔模板。通过扫描电子显微镜（SEM）、衰减全反射 - 傅里叶变换红外光谱（ATR - FTIR）、X射线衍射分析（XRD）和电化学阻抗谱（EIS）对样品进行表征。我们的结果表明，当与二甲基亚砜掺杂的PEDOT：PSS混合时，Cs - Gel - Agar水凝胶的电导率增强，其中在1%（/）时观察到最佳混合比例，电导率值为3.35×10 S/cm。然而，将PEDOT：PSS含量增加到1.5%（/）会导致电导率降低至3.28×10 S/cm。我们使用磷酸盐缓冲盐水（PBS）溶液对多孔水凝胶进行了体外稳定性测试，并通过物理观察和ATR - FTIR表征研究了水凝胶的性能。本研究为基于Cs - Gel - Agar的PEDOT：PSS水凝胶在组织工程中的潜在应用提供了有前景的初步数据，因此，有必要进一步研究以评估它们作为生物相容性支架的能力。

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