Choyam Shilja, Jain Priyanshi M, Kammara Rajagopal
Department of Protein Chemistry and Technology, Faculty of AcSIR, CSIR-CFTRI, Mysore, India.
Front Microbiol. 2021 Aug 24;12:710741. doi: 10.3389/fmicb.2021.710741. eCollection 2021.
An antimicrobial peptide [ antimicrobial peptide (BAMP)] produced by was isolated from the Indian traditional fermented food and characterized. The antimicrobial peptide BAMP showed many unique features such as thermostability (4.0-125°C), pH tolerance (pH 2.0-9.0), and resistance to physiological enzymes (trypsin, chymotrypsin, pepsin, proteinase K, protease, and catalase), and food-grade metal salts do not inhibit the activity. The broad spectrum of BAMP (antimicrobial activity) makes it a suitable candidate for food preservation as well as antimicrobial therapy. BAMP was found to exhibit a bacteriostatic effect on and controls the viability of in chicken meat efficiently. BAMP was found to establish eubiosis, as it is not antagonistic to . Its non-hemolytic nature makes it suitable for therapy. Various genome prediction tools were adopted and applied to understand their localization, gene arrangement, and type of antimicrobials. Founded on its superior functional attributes, BAMP is a potent new-generation antimicrobial peptide.
从印度传统发酵食品中分离出一种由[具体产生菌]产生的抗菌肽[抗菌肽(BAMP)]并对其进行了表征。抗菌肽BAMP具有许多独特特性,如热稳定性(4.0 - 125°C)、耐pH值范围(pH 2.0 - 9.0)以及对生理酶(胰蛋白酶、糜蛋白酶、胃蛋白酶、蛋白酶K、蛋白酶和过氧化氢酶)具有抗性,并且食品级金属盐不会抑制其活性。BAMP的广谱抗菌活性使其成为食品保鲜以及抗菌治疗的合适候选物。发现BAMP对[具体细菌]具有抑菌作用,并能有效控制鸡肉中[具体细菌]的活力。发现BAMP能建立微生态平衡,因为它对[具体有益菌]无拮抗作用。其非溶血性质使其适合用于治疗。采用了各种基因组预测工具来了解它们的定位、基因排列以及抗菌剂类型。基于其卓越的功能特性,BAMP是一种强大的新一代抗菌肽。