Popa Dragos George, Obleagă Cosmin Vasile, Socea Bogdan, Serban Dragos, Ciurea Marius Eugen, Diaconescu Marian, Vîlcea Ionică Daniel, Meșină Cristian, Mirea Cecil, Florescu Dan Nicolae, Baleanu Vlad Dumitru, Comandasu Meda, Tudosie Mihai Silviu, Tribus Laura Carina, Niculescu Bogdan
Department of Plastic and Reconstructive Surgery, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania.
Department of Surgery, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania.
Exp Ther Med. 2021 Oct;22(4):1147. doi: 10.3892/etm.2021.10582. Epub 2021 Aug 9.
The majority of studies concerning () are oriented towards the implication of infection with in processes that end in the formation of neoplasia, without assessing the impact of the bacterium in triggering acute gastroduodenal hemorrhagic episodes. The present study includes 166 patients with upper digestive hemorrhage, admitted to the ATI Clinic, the Gastroenterology Clinic or to the Surgery II Clinic of the County Emergency Clinical Hospital in Craiova, Romania between 2017 and 2019. All patients were monitored for evolution and received treatment according to current guidelines, and hemorrhagic lesions were biopsied. In the study group, 56.8% of the patients with upper gastrointestinal bleeding (UGIB) were positive for and 43.2% were negative. In patients less than 50 years of age, non-steroidal anti-inflammatory drug (NSAID) use and infection had a cumulative effect in causing bleeding lesions, but in patients older than 50 years of age, the use of NSAIDs was replaced by therapies with oral antiplatelet or anticoagulant agents. The need for hemostasis surgery was more common in patients who exhibited -positive UGIB compared to -negative (16 vs. 9.7%). In patients with -positive hemorrhagic lesions, gastric resection was frequently required to obtain hemostasis. Persistence of infection in patients with a history of gastric resection (4.1%) still predisposes to a hemorrhagic or neoplastic complication.
大多数关于（）的研究都聚焦于感染（）在肿瘤形成过程中的影响，而未评估该细菌在引发急性胃十二指肠出血性发作方面的作用。本研究纳入了2017年至2019年期间在罗马尼亚克拉约瓦县急诊临床医院的ATI诊所、胃肠病学诊所或第二外科诊所收治的166例上消化道出血患者。所有患者均接受病情监测，并根据现行指南接受治疗，同时对出血性病变进行活检。在研究组中，56.8%的上消化道出血（UGIB）患者（）检测呈阳性，43.2%呈阴性。在年龄小于50岁的患者中，非甾体抗炎药（NSAID）的使用和（）感染在导致出血性病变方面具有累积效应，但在年龄大于50岁的患者中，NSAID的使用被口服抗血小板或抗凝剂治疗所取代。与（）阴性的UGIB患者相比，（）阳性的UGIB患者更常需要进行止血手术（分别为16%和9.7%）。在（）阳性出血性病变的患者中，常需进行胃切除术以实现止血。有胃切除史的患者中（）感染的持续存在（4.1%）仍易引发出血或肿瘤并发症。
