Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.
Biotechnol J. 2021 Dec;16(12):e2100255. doi: 10.1002/biot.202100255. Epub 2021 Oct 4.
Iron (Fe) and Fe-based materials have been vigorously explored in orthopedic applications in the past decade mainly owing to their promising mechanical properties including high yield strength, elastic modulus and ductility. Nevertheless, their corrosion products and low corrosion kinetics are the major concerns that need to be improved further despite their appealing mechanical strengths. The current studies on porous Fe-based scaffolds show an improved corrosion rate but the in vitro biocompatibility is still problematic in general. Unlike the Mg implants, the biodegradation and bioabsorption of Fe-based implants are still not well described. This vague issue could implicate the development of Fe-based materials as potential medical implants as they have not reached the clinical trial stage yet. Thus, there is a need to understand in-depth the Fe corrosion behavior and its bioabsorption mechanism to facilitate the material design of Fe-based scaffolds and further improve its biocompatibility. This manuscript provides an important insight into the basic bioabsorption of the multi-ranged Fe-based corrosion products with a review of the latest progress on the corrosion & in vitro biocompatibility of porous Fe-based scaffolds together with the remaining challenges and the perspective on the future direction.
在过去十年中，铁（Fe）和铁基材料在骨科应用中得到了大力探索，主要是因为它们具有高屈服强度、弹性模量和延展性等有前途的机械性能。然而，尽管它们具有吸引人的机械强度，但它们的腐蚀产物和低腐蚀动力学仍然是需要进一步改进的主要关注点。目前对多孔铁基支架的研究表明，腐蚀速率有所提高，但总体而言，体外生物相容性仍然存在问题。与镁植入物不同，铁基植入物的生物降解和生物吸收仍未得到很好的描述。这个模糊的问题可能会影响铁基材料作为潜在医用植入物的发展，因为它们尚未进入临床试验阶段。因此，需要深入了解 Fe 的腐蚀行为及其生物吸收机制，以促进铁基支架的材料设计，并进一步提高其生物相容性。本文提供了对多范围 Fe 基腐蚀产物基本生物吸收的重要见解，综述了多孔 Fe 基支架腐蚀和体外生物相容性的最新进展，以及剩余的挑战和未来方向的展望。
