Aro Rudolf, Eriksson Ulrika, Kärrman Anna, Yeung Leo W Y
Man-Technology-Environment (MTM) Research Centre, School of Science and Technology, Örebro University, Örebro SE-701 82 Sweden.
Environ Sci Technol. 2021 Oct 5;55(19):13142-13151. doi: 10.1021/acs.est.1c04031. Epub 2021 Sep 14.
Studies have highlighted the increasing fraction of unidentified organofluorine (UOF) compounds in human blood, whose health effects are not known. In this study, 130 whole blood samples from the Swedish general population were analyzed for extractable organofluorine (EOF) and selected per- and polyfluoroalkyl substances (PFAS). Organofluorine mass balance analysis revealed that 60% (0-99%) of the EOF in female samples could not be explained by the 63 monitored PFAS; in males, 41% (0-93%) of the EOF was of unidentified origin. Significant differences between both age groups and gender were seen, with the highest fraction of UOF in young females (70% UOF, aged 18-44), which is contrary to what has been reported in the literature for commonly monitored compounds (e.g., perfluorooctane sulfonic acid, PFOS). Increasing the number of monitored PFAS did not lead to a large decrease of the UOF fraction; the seven highest PFAS (C8-C11 PFCAs, C6-C8 PFSAs) accounted for 98% of sum 63 PFAS. The high fraction of UOF in human samples is of concern, as the chemical species of these organofluorine compounds remain unknown and thus their potential health risks cannot be assessed.
研究强调了人体血液中未识别有机氟（UOF）化合物的比例不断增加，其对健康的影响尚不清楚。在本研究中，对来自瑞典普通人群的130份全血样本进行了可提取有机氟（EOF）和选定的全氟和多氟烷基物质（PFAS）分析。有机氟质量平衡分析表明，女性样本中60%（0 - 99%）的EOF无法用所监测的63种PFAS来解释；在男性中，41%（0 - 93%）的EOF来源不明。在年龄组和性别之间均观察到显著差异，年轻女性中UOF的比例最高（70%的UOF，年龄在18 - 44岁），这与文献中关于常见监测化合物（如全氟辛烷磺酸，PFOS）的报道相反。增加所监测PFAS的数量并没有导致UOF比例大幅下降；七种含量最高的PFAS（C8 - C11全氟羧酸，C6 - C8全氟磺酸）占63种PFAS总和的98%。人体样本中UOF的高比例令人担忧，因为这些有机氟化合物的化学种类仍然未知，因此无法评估其潜在的健康风险。
