Chemical Science Research Group, Advanced Research Group, Division of Research and Development, Lovely Professional University, Phagwara, Punjab-144411,India.
Department of Chemistry, Pondicherry University, Kalapet, Puducherry- 605014,India.
Curr Top Med Chem. 2021;21(31):2779-2799. doi: 10.2174/1568026621666210916170417.
Infectious diseases have been evolving and re-evolving over the ages and causing immense misery to humans. Among them, some have been prevented and eradicated, but few are still threatening the modern era since their origin. The majority of these infectious diseases are poverty-driven, hence highly prevalent in the lower-income and mid-income countries of Africa and Asia. The world's deadliest infections, including Tuberculosis, Malaria and HIV/AIDS, have been considered as the "Big Three" infectious diseases (BTIDs). With leading infections and deaths every year, the BTIDs have been recognized as the world's greatest pandemics. In light of these alarming situations, this review has been aimed to provide a comprehensive overview of the current status of chemotherapeutics, associated challenges and future perspectives of BTIDs.
传染病在历史长河中不断演变和重新出现，给人类带来了巨大的痛苦。其中一些已经得到预防和根除，但由于其起源，少数传染病仍在威胁着现代社会。这些传染病大多是由贫困引起的，因此在非洲和亚洲的低收入和中等收入国家非常普遍。世界上最致命的传染病，包括结核病、疟疾和艾滋病，被认为是“三大”传染病（BTIDs）。由于每年都有主要的传染病和死亡病例，BTIDs 被认为是世界上最大的流行病。鉴于这些令人担忧的情况，本综述旨在全面概述 BTIDs 的化疗现状、相关挑战和未来展望。
