Zafar Shamaila, Rasul Azhar, Iqbal Javed, Anwar Haseeb, Imran Ali, Jabeen Farhat, Shabbir Asghar, Akram Rabia, Maqbool Javeria, Sajid Faiqa, Arshad Muhammad Umair, Hussain Ghulam, Islam Saiful
Neurochemicalbiology and Genetics Laboratory (NGL) Department of Physiology Faculty of Life Sciences Government College University Faisalabad Pakistan.
Department of Zoology Faculty of Life Sciences Government College University Faisalabad Pakistan.
Food Sci Nutr. 2021 Jul 9;9(9):5016-5027. doi: 10.1002/fsn3.2455. eCollection 2021 Sep.
Peripheral nerve injuries are among those complicated medical conditions, which are still waiting for their highly effective first-line therapies. In this study, the role of crude leaves was evaluated at different doses for their effectiveness in improving functional recovery following sciatic nerve injury-induced in the mouse model. Thirty-two healthy albino mice were divided into four groups as Normal chow group (control, = 8) and chow groups (50 mg/kg ( = 8), 100 mg/kg ( = 8) and 200 mg/kg ( = 8)). Behavioral analyses were performed to assess and compare improved functional recovery along with skeletal muscle mass measurement in all groups. Serum samples were analyzed for oxidative stress markers. Results showed that leaves at dose-dependent manner showed statistically prominent ( < .05) increase in sensorimotor functions reclamation as confirmed by behavioral analyses along with muscle mass restoration and prominent decline in TOS and momentous increase in TAC along with the augmented activity of antioxidative enzymes.
周围神经损伤属于复杂的医学病症，目前仍在等待高效的一线治疗方法。在本研究中，评估了不同剂量的粗叶对改善小鼠模型坐骨神经损伤后功能恢复的有效性。32只健康的白化小鼠被分为四组，即正常饮食组（对照组，n = 8）和饮食组（50 mg/kg（n = 8）、100 mg/kg（n = 8）和200 mg/kg（n = 8））。进行行为分析以评估和比较所有组功能恢复的改善情况以及骨骼肌质量测量。分析血清样本中的氧化应激标志物。结果表明，粗叶以剂量依赖性方式使感觉运动功能恢复有统计学上显著（P < 0.05）的增加，行为分析证实了这一点，同时伴有肌肉质量恢复，总氧化应激（TOS）显著下降，总抗氧化能力（TAC）显著增加，以及抗氧化酶活性增强。
