Chen Peng, Du Zhenlan, Wang Jianfei, Liu Yi, Zhang Juan, Liu Daihong
Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
Chinese PLA Medical School, Beijing, China.
Ann Transl Med. 2021 Aug;9(16):1337. doi: 10.21037/atm-21-3924.
In recent years, the incidence of hematological tumors has increased. The tumor microenvironment (TME) is the local biological environment in the process of tumor occurrence and development and is closely related to hematological malignancies, including lymphoma and leukemia. This study aims to conduct a bibliometric analysis of the research on the hematological TME, reflect the general situation of the research in this field, and remind the focus of future research.
Search the Science Citation Index Expanded (SCI-E) database on the Web of Science Core Collection (WOSCC). Use subject terms to search tumor microenvironment; the limited search subject is Hematology, and the time range is from 1990 to July 18, 2021. Use CiteSpace software to analyze the number of annual papers published, the number of citations, the distribution of disciplines, the distribution of countries/institutions, the distribution of authors, the distribution of journals, and the frequency of use of keywords and its trend of change.
There were 1,992 related research articles cited 77,213 times. The top 5 countries with the number of published papers in this field are: the United States, Italy, China, Germany, and the United Kingdom; the top 5 centrally ranked countries are the United States, Italy, Spain, France, and Japan. Literature and cooperation are mainly from the United States. The top three researchers with several published papers are Anderson KC, Ansell SM, and Gascoyne RD. Their centrality scores are all low, with only 5 researchers reaching above 0.01, and there is less collaboration between the authors. High-quality papers are from , , , and . Keyword analysis shows that immunotherapy is the current focus of research in this field.
The research on the microenvironment of hematological malignancies is rapidly developing. At present, the main research focus is on targeted immunotherapy.
近年来，血液系统肿瘤的发病率有所上升。肿瘤微环境（TME）是肿瘤发生发展过程中的局部生物学环境，与包括淋巴瘤和白血病在内的血液系统恶性肿瘤密切相关。本研究旨在对血液系统肿瘤微环境的研究进行文献计量分析，反映该领域的研究概况，并提示未来研究的重点。
在科学网核心合集（WOSCC）上搜索科学引文索引扩展版（SCI-E）数据库。使用主题词搜索肿瘤微环境；限定检索主题为血液学，时间范围为1990年至2021年7月18日。使用CiteSpace软件分析年度发表论文数量、被引次数、学科分布、国家/机构分布、作者分布、期刊分布以及关键词使用频率及其变化趋势。
共检索到1992篇相关研究论文，被引77213次。该领域发表论文数量排名前5的国家为：美国、意大利、中国、德国和英国；中心性排名前5的国家为美国、意大利、西班牙、法国和日本。文献和合作主要来自美国。发表论文数量排名前三的研究者是安德森·KC、安塞尔·SM和加斯考因·RD。他们的中心性得分均较低，只有5位研究者得分超过0.01，作者之间的合作较少。高质量论文来自[此处原文缺失相关期刊名称]、[此处原文缺失相关期刊名称]、[此处原文缺失相关期刊名称]和[此处原文缺失相关期刊名称]。关键词分析表明，免疫疗法是该领域当前的研究重点。
血液系统恶性肿瘤微环境的研究发展迅速。目前，主要研究重点是靶向免疫疗法。
