Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, 226011, China.
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
J Cardiovasc Transl Res. 2022 Jun;15(3):604-620. doi: 10.1007/s12265-021-10171-3. Epub 2021 Sep 17.
Increasing evidence shows that endothelial cells play critical roles in maintaining vascular homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid leakage, and preventing thrombosis. The damage or injury of endothelial cells induced by physical, chemical, and biological risk factors is a leading contributor to the development of mortal cardiovascular and cerebrovascular diseases. However, the underlying mechanism of endothelial injury remains to be elucidated. Notably, no drugs effectively targeting and mending injured vascular endothelial cells have been approved for clinical practice. There is an urgent need to understand pathways important for repairing injured vasculature that can be targeted with novel therapies. Exercise training-induced protection to endothelial injury has been well documented in clinical trials, and the underlying mechanism has been explored in animal models. This review mainly summarizes the protective effects of exercise on vascular endothelium and the recently identified potential therapeutic targets for endothelial dysfunction.
越来越多的证据表明，内皮细胞在维持血管稳态、调节血管张力、抑制炎症反应、抑制脂质渗漏和防止血栓形成等方面发挥着关键作用。由物理、化学和生物危险因素引起的内皮细胞损伤或损伤是导致致命心血管和脑血管疾病发展的主要原因。然而，内皮损伤的潜在机制仍有待阐明。值得注意的是，目前尚无针对受损血管内皮细胞的有效药物被批准用于临床实践。因此，迫切需要了解修复受损血管的重要途径，以便用新的治疗方法进行靶向治疗。临床试验已经充分证明了运动训练对内皮损伤的保护作用，并且在动物模型中已经探索了其潜在的机制。本综述主要总结了运动对血管内皮的保护作用以及最近发现的内皮功能障碍的潜在治疗靶点。
