State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Phytomedicine. 2022 Jan;95:153727. doi: 10.1016/j.phymed.2021.153727. Epub 2021 Sep 4.
Globally, lung cancer is the leading cause of cancer associated mortalities. The current conventional chemotherapy remains the preferred treatment option for lung cancer, as surgical resection plays little role in the treatment of over 75% of lung cancer patients. Therefore, there is a need to develop novel potential therapeutic drugs or adjuvants with a high efficiency and safety against lung cancer. Scutellaria baicalensis Georgi, a common Chinese medicinal herb that has been in use for more than 2000 years, has recently been shown to possess significant activities against lung cancer. However, current research progress on pharmacological effects and relevant molecular mechanisms of S. baicalensis in lung cancer therapy have not been systematically summarized.
This review aimed at elucidating on the anti-lung cancer mechanisms and antitumor efficacies of S. baicalensis as well as its active ingredients, and providing a valuable reference for further investigation in this field.
We used "Scutellaria baicalensis" or the name of the compound in S. baicalensis, in combination with "lung cancer" as key words to systematically search for relevant literature from the Web of Science and PubMed databases. Publications that investigated molecular mechanisms were the only ones selected for analysis. The PRISMA guidelines were followed.
Fifty-four publications met the inclusion criteria for this study. Five anti-lung cancer mechanisms of S. baicalensis and its constituent components are discussed. These mechanisms include apoptosis induction, cell-cycle arrest, suppression of proliferation, blockade of invasion and metastasis, and overcoming drug-resistance. These compounds exhibited high antitumor efficacies and safety against lung cancer xenografts.
Studies should aim at elucidating on the anti-cancer mechanisms of S. baicalensis to achieve the ultimate goal of lung cancer therapy.
在全球范围内，肺癌是癌症相关死亡率的主要原因。目前的常规化疗仍然是肺癌的首选治疗方法，因为手术切除在超过 75%的肺癌患者的治疗中作用不大。因此，需要开发高效、安全的新型潜在治疗药物或佐剂来治疗肺癌。黄芩是一种常用的中国草药，已经使用了 2000 多年，最近被证明对肺癌具有显著的活性。然而，目前关于黄芩在肺癌治疗中的药理作用和相关分子机制的研究进展尚未得到系统总结。
本综述旨在阐明黄芩及其活性成分的抗肺癌机制和抗肿瘤功效，为该领域的进一步研究提供有价值的参考。
我们使用“黄芩”或黄芩中的化合物名称，结合“肺癌”作为关键词，从 Web of Science 和 PubMed 数据库系统地搜索相关文献。仅选择分析研究分子机制的出版物。
本研究共纳入 54 篇符合条件的文献。讨论了黄芩及其组成成分的 5 种抗肺癌机制。这些机制包括诱导细胞凋亡、细胞周期停滞、抑制增殖、阻断侵袭和转移以及克服耐药性。这些化合物对肺癌异种移植具有很高的抗肿瘤功效和安全性。
研究应旨在阐明黄芩的抗癌机制，以实现肺癌治疗的最终目标。
