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伟大的未来还是贪婪的冒险:精准医学需要哲学。

Great future or greedy venture: Precision medicine needs philosophy.

作者信息

Jiao Fei, Guo Ruoyu, Beckmann Jacques S, Yan Zhonghai, Yang Yun, Hu Jinxia, Wang Xin, Xie Shuyang

机构信息

Department of Biochemistry and Molecular Biology Binzhou Medical University Yantai China.

Faculty of Biology and Medicine University of Lausanne Lausanne Switzerland.

出版信息

Health Sci Rep. 2021 Sep 14;4(3):e376. doi: 10.1002/hsr2.376. eCollection 2021 Sep.

Abstract

INTRODUCTION

Over the past decade, we have witnessed the initiation and implementation of precision medicine (PM), a discipline that promises to individualize and personalize medical management and treatment, rendering them ultimately more precise and effective. Despite of the continuing advances and numerous clinical applications, the potential of PM remains highly controversial, sparking heated debates about its future.

METHOD

The present article reviews the philosophical issues and practical challenges that are critical to the feasibility and implementation of PM.

OUTCOME

The explanation and argument about the relations between PM and computability, uncertainty as well as complexity, show that key foundational assumptions of PM might not be fully validated.

CONCLUSION

The present analysis suggests that our current understanding of PM is probably oversimplified and too superficial. More efforts are needed to realize the hope that PM has elicited, rather than make the term just as a hype.

摘要

引言

在过去十年中,我们见证了精准医学(PM)的兴起与实施,这一学科有望实现医疗管理和治疗的个体化与个性化,最终使其更加精准有效。尽管取得了持续进展并有着众多临床应用,但精准医学的潜力仍极具争议,引发了关于其未来的激烈辩论。

方法

本文回顾了对精准医学的可行性和实施至关重要的哲学问题与实际挑战。

结果

关于精准医学与可计算性、不确定性以及复杂性之间关系的解释和论证表明,精准医学的关键基础假设可能并未得到充分验证。

结论

目前的分析表明,我们目前对精准医学的理解可能过于简化和肤浅。需要付出更多努力来实现精准医学所激发的希望,而不是让这个术语仅仅成为一种炒作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1247/8439431/ac89e7b37484/HSR2-4-e376-g002.jpg

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