State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang 330047, China.
Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Food Chem. 2022 Mar 1;371:131106. doi: 10.1016/j.foodchem.2021.131106. Epub 2021 Sep 9.
Type 2 diabetes (T2D) is a metabolic disease characterized by hyperglycemia. Intake of dietary fiber is inversely associated with risks of T2D. Here, metabolomics and 16S rRNA gene sequencing were employed to investigate the effects of arabinoxylan on gut microbiota and their metabolites in type 2 diabetic rats. T2D increased the abundance of opportunistic pathogens (such as Desulfovibrio and Klebsiella) and the levels of 12α-hydroxylated bile acids and acylcarnitines (C3) in diabetic rats, which eventually contribute to insulin resistance and hyperglycemia. Supplementation with arabinoxylan promoted the growth of fiber-degrading bacteria to increase short-chain fatty acids (SCFAs), as well as decreased the abundance of opportunistic pathogens. Arabinoxylan treatment also decreased the concentrations of 12α-hydroxylated bile acids, and increased the levels of equol, indolepropionate, and eicosadienoic acid. This study indicated that the beneficial effects of arabinoxylan on T2D may be partially attributed to the modification of gut microbiota and related metabolites.
2 型糖尿病（T2D）是一种以高血糖为特征的代谢性疾病。膳食纤维的摄入与 T2D 的风险呈负相关。在这里，代谢组学和 16S rRNA 基因测序被用于研究阿拉伯木聚糖对 2 型糖尿病大鼠肠道微生物群及其代谢物的影响。T2D 增加了机会性病原体（如脱硫弧菌和克雷伯氏菌）的丰度和 12α-羟化胆汁酸和酰基辅酶 A（C3）的水平，这最终导致胰岛素抵抗和高血糖。补充阿拉伯木聚糖促进了纤维降解菌的生长，增加了短链脂肪酸（SCFAs），同时降低了机会性病原体的丰度。阿拉伯木聚糖处理还降低了 12α-羟化胆汁酸的浓度，并增加了大豆苷元、吲哚丙酸和二十碳二烯酸的水平。这项研究表明，阿拉伯木聚糖对 T2D 的有益作用可能部分归因于对肠道微生物群及其相关代谢物的修饰。
