Campus Centro-Oeste Dona Lindu, Federal University of São João Del Rei (UFSJ), Divinopolis, Minas Gerais, Brazil.
Department of Biochemistry and Tissue Biology Department, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Nat Prod Res. 2022 Sep;36(17):4435-4438. doi: 10.1080/14786419.2021.1980791. Epub 2021 Sep 21.
Chenopodin is an 11S-type globulin purified from seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits anti-inflammatory activity.
藜蛋白是从种子中纯化得到的 11S 型球蛋白，能够结合碳水化合物并使人类红细胞发生凝集。本研究旨在评估杂合藜蛋白的 N 端结构及其在炎症模型中的作用。藜蛋白的结构上有两个亚基，并且其 N 端与其他藜蛋白同源性为 92%。藜蛋白可减少角叉菜胶诱导的小鼠足肿胀和中性粒细胞浸润。综上，我们证实藜蛋白具有抗炎活性。
