State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, PR China.
State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, Chengdu, PR China; Chongqing Key Laboratory for Disease Proteomics, Chongqing, Chengdu, PR China.
Curr Opin Pharmacol. 2021 Dec;61:12-20. doi: 10.1016/j.coph.2021.08.011. Epub 2021 Sep 20.
Serine lies at a critical node in biological processes involved in supplying intermediates for redox homeostasis, nucleotide, or lipid biosynthesis and one-carbon metabolism-coupled methyl donor production. Recently, dietary serine supplementation has been reported to modulate cellular serine levels and ameliorate neurological abnormalities induced by serine deficiency. Moreover, growing evidence showed that serine supplementation also alleviates fatty liver, encephalopathy, diabetes mellitus, and related complications, indicating the possibility of serine supplementation as a complementary therapeutic option. However, considering the serine addiction observed in tumorigenesis and tumor development, limitations may exist regarding the application of dietary serine supplementation in patients with cancer. Here, we assess recent research toward the mechanistic understanding of serine supplementation in various diseases to improve our cognition on modulating serine levels in different patients.
丝氨酸位于参与提供氧化还原稳态、核苷酸或脂质生物合成以及一碳代谢偶联甲基供体产生的中间产物的生物学过程的关键节点。最近，有报道称膳食丝氨酸补充可以调节细胞丝氨酸水平，并改善由丝氨酸缺乏引起的神经异常。此外，越来越多的证据表明，丝氨酸补充还可以减轻脂肪肝、脑病、糖尿病及其相关并发症，表明丝氨酸补充作为一种补充治疗选择的可能性。然而，考虑到在肿瘤发生和肿瘤发展中观察到的丝氨酸成瘾，在癌症患者中应用膳食丝氨酸补充可能存在局限性。在这里，我们评估了最近在各种疾病中对丝氨酸补充的机制理解的研究，以提高我们对不同患者调节丝氨酸水平的认识。
