Acute promyelocytic leukemia: report of a variant translocation, t(1;17).

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作者信息

Schwartz J G, Clare N, Hansen K, Britton H, Manhoff L

出版信息

Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):89-93. doi: 10.1016/0165-4608(86)90110-x.

DOI:10.1016/0165-4608(86)90110-x

PMID:3455864

Abstract

A 4-year-old female with acute promyelocytic leukemia (APL) was found to have a variant form of the 15;17 translocation, which is diagnostic of APL. The karyotype of the malignant cells was 47,XX,t(1;11)(q25;q21),t(1;17)(p36;q21), + 8. This case is additional evidence that the breakpoint of #17 at q21 is the characteristic chromosomal aberration of APL. The present case is also unusual because of the young age of the patient.

摘要