Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Switzerland; Department of Psychology, University of Otago, Dunedin, New Zealand; Wellcome Centre for Integrative Neuroimaging, and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging, and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Biol Psychol. 2021 Oct;165:108193. doi: 10.1016/j.biopsycho.2021.108193. Epub 2021 Sep 22.
It is poorly understood why asthma symptoms are often discordant with objective medical tests. Differences in interoception (perception of internal bodily processes) may help explain symptom discordance, which may be further influenced by mood and attention. We explored inter-relationships between interoception, mood and attention in 63 individuals with asthma and 30 controls. Questionnaires, a breathing-related interoception task, two attention tasks, and standard clinical assessments were performed. Questionnaires were analysed using exploratory factor analysis, and linear regression examined relationships between measures. K-means clustering also defined asthma subgroups. Two concordant asthma subgroups (symptoms related appropriately to pathophysiology, normal mood) and one discordant subgroup (moderate symptoms, minor pathophysiology, low mood) were found. In all participants, negative mood correlated with decreased interoceptive ability and faster reaction times in an attention task. Our findings suggest that interpreting bodily sensations relates to mood, and this effect may be heightened in subgroups of individuals with asthma.
人们对哮喘症状与客观医学测试常常不一致的原因知之甚少。内脏感知（对内部身体过程的感知）的差异可能有助于解释症状不一致，而情绪和注意力可能进一步影响症状不一致。我们在 63 名哮喘患者和 30 名对照者中探讨了内脏感知、情绪和注意力之间的相互关系。进行了问卷调查、与呼吸相关的内脏感知任务、两项注意力任务和标准临床评估。使用探索性因子分析对问卷进行分析，并使用线性回归检验各测量指标之间的关系。K-均值聚类还定义了哮喘亚组。发现了两个一致的哮喘亚组（症状与病理生理学相关，情绪正常）和一个不一致的亚组（症状中等，病理生理学较小，情绪低落）。在所有参与者中，负性情绪与较低的内脏感知能力和注意力任务中更快的反应时间相关。我们的研究结果表明，对身体感觉的解释与情绪有关，而在哮喘患者的亚组中，这种影响可能更为明显。
