Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland; Department of Psychology, University of Otago, Dunedin, New Zealand; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
Neuron. 2021 Dec 15;109(24):4080-4093.e8. doi: 10.1016/j.neuron.2021.09.045. Epub 2021 Oct 20.
Interoception, the perception of internal bodily states, is thought to be inextricably linked to affective qualities such as anxiety. Although interoception spans sensory to metacognitive processing, it is not clear whether anxiety is differentially related to these processing levels. Here we investigated this question in the domain of breathing, using computational modeling and high-field (7 T) fMRI to assess brain activity relating to dynamic changes in inspiratory resistance of varying predictability. Notably, the anterior insula was associated with both breathing-related prediction certainty and prediction errors, suggesting an important role in representing and updating models of the body. Individuals with low versus moderate anxiety traits showed differential anterior insula activity for prediction certainty. Multi-modal analyses of data from fMRI, computational assessments of breathing-related metacognition, and questionnaires demonstrated that anxiety-interoception links span all levels from perceptual sensitivity to metacognition, with strong effects seen at higher levels of interoceptive processes.
内感受，即对内部身体状态的感知，被认为与情感特质（如焦虑）密切相关。尽管内感受涉及从感觉到元认知的加工，但目前尚不清楚焦虑是否与这些加工水平存在差异相关。在这里，我们使用计算模型和高场（7T） fMRI 来研究呼吸领域的这一问题，以评估与吸气阻力的动态变化相关的大脑活动，这些变化的可预测性各不相同。值得注意的是，前岛叶与呼吸相关的预测确定性和预测误差都有关联，这表明其在代表和更新身体模型方面具有重要作用。与中低度焦虑特质的个体相比，低焦虑特质的个体在前岛叶的预测确定性方面表现出不同的活动。对来自 fMRI、呼吸相关元认知的计算评估以及问卷调查的数据进行的多模态分析表明，焦虑与内感受的联系跨越了从感知敏感性到元认知的所有水平，在更高水平的内感受过程中观察到了强烈的影响。
