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表现为慢性化脓性脓肿的上颌骨骨肉瘤:病例报告

Osteosarcoma of the maxilla presenting as a chronic pyogenic abscess: A case report.

作者信息

Sain Baijaeek, Gupta Arnab, Ghosh Saradindu, Mondal Radha Raman, Bhattacharya Samir, Ghose Aruni

机构信息

Dept. of Surgical Oncology, Saroj Gupta Cancer Centre and Research Institute Kolkata, India.

Dept. of Surgical Oncology, Saroj Gupta Cancer Centre and Research Institute Kolkata, India.

出版信息

Int J Surg Case Rep. 2021 Oct;87:106425. doi: 10.1016/j.ijscr.2021.106425. Epub 2021 Sep 20.

Abstract

INTRODUCTION

Osteosarcoma of the maxilla is recorded as the least common of all bone malignancies. It exhibits a clinical behavior and natural history distinct from their counterparts of the trunk and extremities. Transformation from a chronic pyogenic abscess of the maxilla is even more unusual.

CASE SUMMARY

A 70 year old lady presented to our hospital with a hard, fixed and tender bony swelling in her left cheek. She had initially presented to a different hospital with a similar presentation which was excised after imaging and post excision was found to be a chronic pyogenic abscess. The swelling reappeared within one year and on re-excision was found to be a low grade paraosteal osteosarcoma of the hard palate. CECT and PET-CT work-up at our hospital showed a left maxillary sinus growth with prominent neck lymph nodes along with mediastinal lymphadenopathy and pulmonary metastasis. Final histopathology revealed ulcerated stratified squamous epithelium mucosa overlying a lesion suggestive of osteosarcoma.

DISCUSSION

Complete surgical excision with negative margins continues to be the mainstay of treatment, but osteosarcomas of maxillofacial region pose difficulties in obtaining tumour free margins because of their complex anatomy around the cranium. Surgery may be complemented by radiotherapy with or without chemotherapy. Small size of the tumour and low-grade histology have been assumed to reflect a better prognosis.

CONCLUSION

Osteosarcoma of maxillofacial region has variable appearance clinically as well as radiologically posing a diagnostic challenge for clinicians. Any chronic abscess or recurrent cheek swelling thus necessitates further suspicion and requires a full work-up to rule out this high risk malignancy.

摘要

引言

上颌骨肉瘤是所有骨恶性肿瘤中记录为最不常见的。它表现出与躯干和四肢骨肉瘤不同的临床行为和自然病程。由上颌慢性化脓性脓肿转变而来的情况更为罕见。

病例摘要

一位70岁女性因左侧脸颊出现坚硬、固定且压痛的骨性肿胀前来我院就诊。她最初因类似表现就诊于另一家医院,经影像学检查后切除,术后发现为慢性化脓性脓肿。该肿胀在一年内复发,再次切除后发现是硬腭的低级别骨膜外骨肉瘤。我院的CT增强扫描(CECT)和正电子发射断层显像X线计算机断层扫描(PET-CT)检查显示左上颌窦肿物,并伴有明显的颈部淋巴结肿大以及纵隔淋巴结病和肺转移。最终组织病理学检查显示溃疡的复层鳞状上皮黏膜覆盖在一个提示骨肉瘤的病变之上。

讨论

手术切缘阴性的完整手术切除仍然是主要的治疗方法,但由于颌面部骨肉瘤在颅骨周围解剖结构复杂,在获得无瘤切缘方面存在困难。手术可辅以放疗,或联合化疗。肿瘤体积小和组织学分级低被认为预示着较好的预后。

结论

颌面部骨肉瘤在临床和影像学上外观各异,给临床医生带来诊断挑战。因此,任何慢性脓肿或复发性脸颊肿胀都需要进一步怀疑,并需要进行全面检查以排除这种高风险恶性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fd7/8473757/6a63b5e3b7c5/gr1.jpg

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