Department of Pharmacy, University of Oslo, Oslo, Norway.
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Sep Sci. 2022 Jan;45(1):246-257. doi: 10.1002/jssc.202100603. Epub 2021 Oct 5.
Electromembrane extraction is a microextraction technique where charged analytes are extracted across a supported liquid membrane and selectively isolated from the sample based on an electrical field. Since the introduction in 2006, there has been continuously increasing interest in electromembrane extraction, and currently close to 50 new articles are published per year. Electromembrane extraction can be performed in different technical configurations, based on standard laboratory glass vials or 96-well plate systems, and applications are typically related to pharmaceutical, environmental, and food and beverages analysis. In addition to this, conceptual research has developed electromembrane extraction into different milli- and microfluidic formats. These are much more early-stage activities, but applications among others related to organ-on-chip systems and smartphone detection indicate unique perspectives. To stimulate more research in this direction, the current article reviews the scientific literature on electromembrane extraction in milli- and microfluidic formats. About 20 original research articles have been published on this subject so far, and these are discussed critically in the following. Based on this and the authors own experiences with the topic, we discuss perspectives, challenges, and future research.
电渗析萃取是一种微萃取技术，其中带电荷的分析物在支撑液膜中被萃取，并基于电场从样品中选择性地分离出来。自 2006 年引入以来，电渗析萃取的兴趣持续增加，目前每年接近发表 50 篇新文章。电渗析萃取可以在不同的技术配置中进行，基于标准实验室玻璃小瓶或 96 孔板系统，应用通常与药物、环境和食品与饮料分析有关。除此之外，概念研究已经将电渗析萃取发展成不同的毫微微流控格式。这些都是更早期的活动，但在器官芯片系统和智能手机检测等方面的应用表明了独特的前景。为了刺激这方面的更多研究，本文综述了毫微微流控格式的电渗析萃取的科学文献。迄今为止，已经有大约 20 篇关于这个主题的原始研究文章发表，以下对这些文章进行了批判性讨论。基于这一点以及作者自己在该主题上的经验，我们讨论了前景、挑战和未来的研究。
