The Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, Birmingham, UK.
Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.
Syst Rev. 2021 Sep 27;10(1):259. doi: 10.1186/s13643-021-01811-5.
Adult scoliosis represents a distinct subgroup of scoliosis patients for whom the diagnosis can have a large impact on their health-related quality of life (HR-QOL). Therefore, HR-QOL patient-reported outcome measures (PROMs) are essential to assess disease progression and the impact of interventions. The objective of this systematic review is to evaluate the measurement properties of HR-QOL PROMs in adult scoliosis patients.
We will conduct a literature search, from their inception onwards, of multiple electronic databases including AMED, CINAHL, EMBASE, Medline, PsychINFO and PubMed. The searches will be performed in two stages. For both stages of the search, participants will be aged 18 and over with a diagnosis of scoliosis. The primary outcome of interest in the stage one searches will be studies which use PROMs to investigate HR-QOL as defined by the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy, the secondary outcome will be to assess the frequency of use of the various PROMs. In stage two, the primary outcome of interest will be studies which assess the measurement properties of the HR-QOL PROMs identified in stage one. No specific measurement property will be given priority. No planned secondary outcomes have been identified but will be reported if discovered. In stage one, the only restriction on study design will be the exclusion of systematic reviews. In Stage two the only restriction on study design will be the exclusion of full-text articles not available in the English language. Two reviewers will independently screen all citations and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or risk of bias) will be appraised using the Consensus-based Standards for the selection of Health Measurement Instruments (COSMIN) checklist. The overall strength of the body of evidence will then be assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. A narrative synthesis will be provided with information presented in the main text and tables to summarise and explain the characteristics and findings of the included studies. The narrative synthesis will explore the evidence for currently used PROMs in adult scoliosis patients and any areas that require further study.
The review will help clinicians and researchers identify a HR-QOL PROM for use in patients with adult scoliosis. Findings from the review will be published and disseminated through a peer-reviewed journal and conference presentations.
This systematic review has been registered with the International Prospective Register of Systematic Reviews (PROSPERO), reference number: CRD42020219437.
成人脊柱侧凸是脊柱侧凸患者的一个特殊亚组，其诊断对患者的健康相关生活质量（HR-QOL）有很大影响。因此，HR-QOL 患者报告结局测量（PROM）对于评估疾病进展和干预措施的影响至关重要。本系统评价的目的是评估成人脊柱侧凸患者 HR-QOL PROM 的测量特性。
我们将从多个电子数据库（包括 AMED、CINAHL、EMBASE、Medline、PsychINFO 和 PubMed）中进行文献检索，从其开始进行。检索将分两个阶段进行。在两个阶段的搜索中，参与者的年龄都在 18 岁及以上，且被诊断为脊柱侧凸。第一阶段搜索的主要结果将是使用 PROM 来调查 COME 疗效试验（COMET）分类学定义的 HR-QOL 的研究，次要结果将是评估各种 PROM 的使用频率。在第二阶段，主要结果将是评估在第一阶段确定的 HR-QOL PROM 的测量特性的研究。不会优先考虑任何特定的测量特性。目前没有确定计划的次要结果，但如果发现，将报告这些结果。在第一阶段，对研究设计的唯一限制是排除系统评价。在第二阶段，对研究设计的唯一限制是排除英文全文不可用的文章。两位评审员将独立筛选所有引文和摘要数据。潜在的冲突将通过讨论解决。研究方法学质量（或偏倚风险）将使用基于共识的健康测量仪器选择标准（COSMIN）检查表进行评估。然后使用推荐评估、制定与评价（GRADE）方法评估证据的总体强度。将提供叙述性综合，以主要文本和表格中的信息总结和解释纳入研究的特征和发现。叙述性综合将探讨成人脊柱侧凸患者目前使用的 PROM 的证据，以及需要进一步研究的任何领域。
该综述将帮助临床医生和研究人员确定用于成人脊柱侧凸患者的 HR-QOL PROM。综述结果将通过同行评议期刊和会议报告发表和传播。
本系统评价已在国际前瞻性系统评价注册库（PROSPERO）中注册，参考编号：CRD42020219437。
