Sonkar Satyendra Kumar, Parmar Krishnapal Singh, Ahmad Mohammad Kaleem, Sonkar Gyanendra Kumar, Gautam Medhavi
Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.
J Family Med Prim Care. 2021 Jul;10(7):2594-2599. doi: 10.4103/jfmpc.jfmpc_2395_20. Epub 2021 Jul 30.
Insulin action of reducing blood glucose has been found to be enhanced by trace elements.
This was a cross sectional study including 150 patients with Type 2 Diabetes Mellitus (T2DM) and 50 controls. Serum concentrations of zinc, copper, chromium, selenium and magnesium was measured by colorimetric kit. Fasting Blood Glucose and Glycated Haemoglobin (HbA1c) were assayed using the standard kit.
Out of 150 patients, 85.4% ( = 128) of the cases had uncontrolled blood sugar with HbA1c ≥7 and only 14.6% ( = 22) had good control of blood sugar with HbA1c <7%. Hypertension (42%) and hypothyroidism (14%) were the most commonly associated comorbidities among patients with T2DM. Following percentage of diabetic patients had complications such as peripheral neuropathy (45.3%), diabetic retinopathy (36.7%), coronary artery disease (20.7%), diabetic nephropathy (17.3%), peripheral vascular disease (8.7%), and cerebrovascular accident (6%) respectively. The mean level of zinc, copper, selenium and magnesium was significantly lower in patients with T2DM than the control cases (62.89 vs. 74.95 μg/dL, < 0.05; 116.30 vs. 150.39 μg/dL, < 0.001; 8.57 vs. 16.16 μg/dL, < 0.001; 1.92 vs. 2.31 mg/dL, < 0.05, respectively). Multivariate analysis showed that there was a significant trend between levels of zinc, copper, selenium, and magnesium and the prevalence of T2DM.
The levels of selenium, zinc, copper, and magnesium were significantly lower in patients with T2DM when compared to healthy counterparts.
已发现微量元素可增强胰岛素降低血糖的作用。
这是一项横断面研究，纳入了150例2型糖尿病（T2DM）患者和50例对照。采用比色试剂盒测定血清锌、铜、铬、硒和镁的浓度。使用标准试剂盒检测空腹血糖和糖化血红蛋白（HbA1c）。
150例患者中，85.4%（n = 128）的病例血糖控制不佳，HbA1c≥7，仅有14.6%（n = 22）的病例血糖控制良好，HbA1c<7%。高血压（42%）和甲状腺功能减退（14%）是T2DM患者中最常见的合并症。糖尿病患者出现并发症的比例分别为周围神经病变（45.3%）、糖尿病视网膜病变（36.7%）、冠状动脉疾病（20.7%）、糖尿病肾病（17.3%）、周围血管疾病（8.7%）和脑血管意外（6%）。T2DM患者锌、铜、硒和镁的平均水平显著低于对照病例（分别为62.89 vs. 74.95 μg/dL，P<0.05；116.30 vs. 150.39 μg/dL，P<0.001；8.57 vs. 16.16 μg/dL，P<0.001；1.92 vs. 2.31 mg/dL，P<0.05）。多变量分析显示，锌、铜、硒和镁的水平与T2DM的患病率之间存在显著趋势。
与健康对照相比，T2DM患者的硒、锌、铜和镁水平显著降低。
