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ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.吸烟者和 COPD 患者小气道上皮中的 ACE-2 表达:对 COVID-19 的影响。
Eur Respir J. 2020 May 14;55(5). doi: 10.1183/13993003.00688-2020. Print 2020 May.
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Covid-19 in Critically Ill Patients in the Seattle Region - Case Series.西雅图地区危重症新冠患者-病例系列。
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Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020.2020 年 2 月 12 日至 3 月 16 日,美国 2019 冠状病毒病(COVID-19)患者的严重结局。
MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):343-346. doi: 10.15585/mmwr.mm6912e2.
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COVID-19 and smoking: A systematic review of the evidence.2019冠状病毒病与吸烟:证据的系统评价
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Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients.老年 COVID-19 患者的临床特征:与中青年患者的比较。
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉成人 COVID-19 住院患者的临床病程和死亡危险因素:一项回顾性队列研究。
Lancet. 2020 Mar 28;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3. Epub 2020 Mar 11.
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Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.九名孕妇感染 COVID-19 的临床特征和宫内垂直传播潜力:病历回顾性研究。
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Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease.分析与 2019 年新型冠状病毒病住院患者疾病结局相关的因素。
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新冠病毒病(Covid-19)症状患者有创通气(插管)预后评估

Evaluation of invasive ventilation (intubation) prognosis in patients with Covid-19 symptoms.

作者信息

Farzan Nina, Vahabi Sepideh, Foroghi Ghomi Seyed Yaser, Shirvani Reza, Madani Shima Sadat Hashemi, Shakeri Mansoureh, Araghi Mahmood, Birjandi Mehdi, Farzan Behrooz

机构信息

Emergency Medicine, Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.

Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran.

出版信息

Int J Surg Open. 2020;27:149-153. doi: 10.1016/j.ijso.2020.11.008. Epub 2020 Nov 16.

DOI:10.1016/j.ijso.2020.11.008
PMID:34568616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7667390/
Abstract

BACKGROUND

Coronavirus 2019 (COVID 19) has been reported as a pandemic by the world health organization. Increasing number of cases and associated mortality have demanded the need for clinical studies and researches.

OBJECTIVE

The aim of this study is to evaluate intubation prognosis of the COVID 19 patients referred to Shahid Beheshti hospital in Qom city.

METHOD

COVID 19 patients referred to (XXX)were included in this study. Clinical sign and symptoms were recorded for each patient in a questionnaire. The diagnosis was made using real time polymerase chain reaction and chest CT scans. Lab findings from renal and liver function tests, blood count, c-reactive protein and electrolytes were also recorded. Shortness of breath was measured using oxygen saturation levels in these patients. The data was recorded in the electronic form and was analyzed using SPSS v21.

RESULT

Of 317 patients included in this study, the average age of COVID 19 patients were 59.71 ± 16.46 years. The need of ventilation among the patients older than 50 years was significantly higher than younger patients, p = 0.013. Smoking status, gender and drug addiction was not associated with the need of invasive mechanical ventilation, p = 0.73, p = 0.44 and p = 0.76. Patients need invasive mechanical ventilation compared to those receiving non-invasive ventilation were significantly older, p = 0.001.

CONCLUSION

The need of mechanical ventilation is significantly greater in advanced age COVID-19 patients.

摘要

背景

世界卫生组织已将2019冠状病毒病(COVID-19)报告为大流行病。病例数量和相关死亡率的增加促使有必要开展临床研究。

目的

本研究旨在评估转诊至库姆市沙希德·贝赫什提医院的COVID-19患者的插管预后。

方法

本研究纳入转诊至(XXX)的COVID-19患者。通过问卷记录每位患者的临床症状和体征。采用实时聚合酶链反应和胸部CT扫描进行诊断。还记录了肾功能和肝功能检查、血常规、C反应蛋白和电解质的实验室检查结果。通过这些患者的血氧饱和度水平来测量呼吸急促情况。数据以电子形式记录,并使用SPSS v21进行分析。

结果

本研究纳入的317例患者中,COVID-19患者的平均年龄为59.71±16.46岁。50岁以上患者的通气需求显著高于年轻患者,p = 0.013。吸烟状况、性别和药物成瘾与有创机械通气需求无关,p = 0.73、p = 0.44和p = 0.76。与接受无创通气的患者相比,需要有创机械通气的患者年龄显著更大,p = 0.001。

结论

高龄COVID-19患者的机械通气需求显著更高。