Gonzalez Castro L Nicolas, Wesseling Pieter
Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Neurooncol Pract. 2020 Aug 29;8(1):4-10. doi: 10.1093/nop/npaa055. eCollection 2021 Feb.
Over the past 4 years, advances in molecular pathology have enhanced our understanding of CNS tumors, providing new elements to refine their classification and improve the 2016 World Health Organization (WHO) Classification of CNS tumors. The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official WHO (cIMPACT-NOW) was formed in late 2016 by a group of neuropathology and neuro-oncology experts to provide practical recommendations (published as cIMPACT-NOW updates) to improve the diagnosis and classification of CNS tumors, in advance of the publication of a new WHO Classification of CNS tumors. Here we review the content of all the available cIMPACT-NOW updates and discuss the implications of each update for the diagnosis and management of patients with CNS tumors.
在过去4年中，分子病理学的进展加深了我们对中枢神经系统肿瘤的理解，为完善其分类并改进2016年世界卫生组织（WHO）中枢神经系统肿瘤分类提供了新的要素。2016年末，一组神经病理学和神经肿瘤学专家成立了中枢神经系统肿瘤分类分子与实践方法咨询联盟——非WHO官方组织（cIMPACT-NOW），以便在新版WHO中枢神经系统肿瘤分类发布之前，提供实用建议（以cIMPACT-NOW更新版形式发布），以改善中枢神经系统肿瘤的诊断和分类。在此，我们回顾了所有可用的cIMPACT-NOW更新版内容，并讨论了每次更新对中枢神经系统肿瘤患者诊断和管理的影响。
