Vassalini Paolo, Serra Riccardo, Tarsitani Lorenzo, Koukopoulos Alexia E, Borrazzo Cristian, Alessi Federica, Di Nicolantonio Chiara, Tosato Cecilia, Alessandri Francesco, Ceccarelli Giancarlo, Mastroianni Claudio Maria, d'Ettorre Gabriella
Department of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.
Brain Sci. 2021 Sep 5;11(9):1175. doi: 10.3390/brainsci11091175.
Individuals affected by Coronavirus Disease 2019 (COVID-19) may experience psychiatric symptoms, including depression and suicidal ideation, that could lead to chronic impairment and a reduction in quality of life. Specifically, depressive disorder shows high incidence and may lead to chronic impairment and a reduction in the quality of life. To date, no studies on the presence of suicidality and quantitative analysis of depressive symptoms and their risk factors have yet been published. In this study, we aim to assess the prevalence of depressive symptoms and related risk factors at 3 months after discharge to home care following hospitalization for COVID-19 infection.
Participants were contacted three months after hospital discharge from one of the five COVID-19 hospitals in Rome, as part of a larger project on health outcomes in COVID-19 inpatients (Long Term Neuropsychiatric Disorder in COVID-19 Project), and the Patient Health Questionnaire-9 (PHQ-9) was administered by telephone interview.
Of 115 participants, 14.8% (N = 17) received a PHQ-9-based diagnosis of depression, and = 7 of them scored 1 or more on the item on suicidality. A linear regression model showed the predictive role of female sex, pulmonary chronic condition and previous mental disorder in the development of depressive disorder; the latter was confirmed also by binary logistic regression. Severity indexes of disease (length of hospitalization and intensive care treatment) were found not to be associated with the development of depressive symptoms.
A small but clinically meaningful number of participants in the current study reported that they experienced symptoms of depression and suicidal ideation 3 months post-discharge from their COVID-19 hospitalization. In particular, given the findings that a history of prior psychiatric disorders was predictive of the development of depression symptoms, clinicians should carefully monitor for the presence of all psychiatric symptoms at follow-up visits.
感染2019冠状病毒病（COVID - 19）的个体可能会出现精神症状，包括抑郁和自杀意念，这可能导致慢性功能损害和生活质量下降。具体而言，抑郁症发病率很高，可能导致慢性功能损害和生活质量下降。迄今为止，尚未发表关于自杀倾向的存在以及抑郁症状及其危险因素的定量分析的研究。在本研究中，我们旨在评估COVID - 19感染住院后出院回家接受家庭护理3个月时抑郁症状的患病率及相关危险因素。
作为一项关于COVID - 19住院患者健康结局的大型项目（COVID - 19项目中的长期神经精神障碍）的一部分，在罗马五家COVID - 19医院之一出院三个月后联系参与者，并通过电话访谈进行患者健康问卷9项版（PHQ - 9）调查。
在115名参与者中，14.8%（N = 17）基于PHQ - 9被诊断为抑郁症，其中7人在自杀意念项目上得分1分或更高。线性回归模型显示女性性别、肺部慢性疾病和既往精神障碍在抑郁症发生中的预测作用；二元逻辑回归也证实了后者。发现疾病严重程度指标（住院时间和重症监护治疗时间）与抑郁症状的发生无关。
本研究中有一小部分但具有临床意义的参与者报告称，他们在COVID - 19住院出院3个月后出现了抑郁症状和自杀意念。特别是，鉴于既往精神障碍史可预测抑郁症状的发生这一发现，临床医生在随访时应仔细监测所有精神症状的存在。
