Impact of spp. on the Integrity of the Porcine Gut.

() is the most common food-borne zoonosis in humans, which mainly manifests with watery to bloody diarrhoea. While is responsible for most cases of infection, is less frequently encountered. The object of the study was to prove the clinical impact of mono- and co-colonisation of and on weaned piglets in an infection model and to investigate the impact on transepithelial transport processes in the jejunum and caecum. At an age of eight weeks, eight pigs were infected with (ST-5777), 10 pigs with (ST-122), eight pigs with both strains, and 11 piglets served as control. During the four-week observation period, no clinical signs were observed. During dissection, both strains could be isolated from the jejunum and the caecum, but no alteration of the tissue could be determined histopathologically. Mono-infection with showed an impact on transepithelial ion transport processes of the caecum. An increase in the short circuit current (I) was observed in the Ussing chamber resulting from carbachol- and forskolin-mediated Cl secretion. Therefore, we speculate that caecal colonisation of might affect the transport mechanisms of the intestinal mucosa without detectable inflammatory reaction.