Oh Ju Kyoung, Vasquez Robie, Hwang In-Chan, Oh Ye Na, Kim Sang Hoon, Kang Shin Ho, Joung Jae Yeon, Oh Nam Su, Kim Sejeong, Yoon Yohan, Kang Dae-Kyung
Department of Animal Resources Science, Dankook University, Cheonan 31116, Korea.
R&D Center, Seoul Dairy Cooperative, Ansan 15407, Korea.
Microorganisms. 2021 Sep 8;9(9):1908. doi: 10.3390/microorganisms9091908.
The aim of the presented study was to investigate the synbiotic effects of 4B15 and extract administration on the gut microbiota and obesity-associated metabolic parameters in diet-induced obese mice. Thirty-one 6-week-old male C57BL/N6 mice were divided into five diet groups: normal diet (ND, = 7) group; high-fat diet (HFD, = 6) group; probiotic (PRO, = 5) group; prebiotic (PRE, = 7) group; and synbiotic (SYN, = 6) group. After 10 weeks, the percent of fat mass, serum triglyceride, and ALT levels were significantly reduced in SYN-fed obese mice, compared with other treatments. SYN treatment also modulated the abundance of , , , , , unclassified Clostridiaceae, , , , , , unclassified Erysipelotrichaceae, and unclassified Desulfovibrionaceae. These taxa showed a strong correlation with obesity-associated indices. Lastly, the SYN-supplemented diet upregulated metabolic pathways known to improve metabolic health. Further investigations are needed to understand the mechanisms driving the synbiotic effect of and 4B15.
本研究的目的是探讨4B15和提取物给药对饮食诱导肥胖小鼠肠道微生物群和肥胖相关代谢参数的合生元效应。将31只6周龄雄性C57BL/N6小鼠分为五个饮食组：正常饮食（ND，n = 7）组；高脂饮食（HFD，n = 6）组；益生菌（PRO，n = 5）组；益生元（PRE，n = 7）组；和合生元（SYN，n = 6）组。10周后，与其他处理相比，接受SYN喂养的肥胖小鼠的脂肪量百分比、血清甘油三酯和ALT水平显著降低。SYN处理还调节了、、、、、未分类的梭菌科、、、、、、未分类的丹毒丝菌科和未分类的脱硫弧菌科的丰度。这些分类群与肥胖相关指标显示出强烈的相关性。最后，补充SYN的饮食上调了已知可改善代谢健康的代谢途径。需要进一步研究以了解驱动和4B15合生元效应的机制。
