Laser Center, Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Optics and Laser Engineering Group, Department of Industrial Technologies, Urmia University of Technology (UUT), Urmia 57166-17165, Iran.
Molecules. 2021 Sep 14;26(18):5585. doi: 10.3390/molecules26185585.
A photonic biochip with a tunable response in the visible range is suggested for blood cell sorting applications. Multi-layers of ZnS and Ge slabs (as the main building blocks), hosting a cell in which bio-sample could be injected, are considered as the core of the sensor. In order to increase the sensitivity of the chip, the bio-cell is capsulated inside air slabs, and its walls are coated with graphene sheets. Paying special attention to white and red blood components, the optimum values for structural parameters are extracted first. Tunability of the sensor detectivity is then explored by finding the role of the probe light incident angle, as well as its polarization. The strain of the graphene layer and angle in which it is applied are also suggested to further improve the performance tunability. Results reflect that the biochip can effectively identify selected components through their induced different optical features, besides of the different figure of merit and sensitivity amounts that are recorded for them by the sensor.
提出了一种在可见光谱范围内具有可调响应的光子生物芯片，用于血细胞分选应用。多层 ZnS 和 Ge 平板（作为主要构建块），其中包含一个可以注入生物样本的细胞，被认为是传感器的核心。为了提高芯片的灵敏度，将生物细胞封装在空气平板内，并在其壁上涂覆石墨烯片。特别关注白细胞和红细胞成分，首先提取结构参数的最佳值。然后通过寻找探针光入射角以及其偏振的作用来探索传感器探测率的可调谐性。还建议调整石墨烯层的应变和施加角度，以进一步提高性能的可调谐性。结果表明，该生物芯片可以通过其诱导的不同光学特性有效地识别选定的成分，此外，传感器还记录了它们不同的优值和灵敏度。
