Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, Belgium.
Evolutionary Ecology Group, Department of Biology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Viruses. 2021 Sep 15;13(9):1842. doi: 10.3390/v13091842.
Recent years have witnessed the discovery of several new viruses belonging to the family , expanding the known diversity and host range of this group of complex RNA viruses. Although the pathological relevance of these new viruses is not always clear, several well-studied members of the family are known to be important animal pathogens. Here, we report the complete genome sequences of four new arterivirus variants, belonging to two putative novel species. These new arteriviruses were discovered in African rodents and were given the names Lopma virus and Praja virus. Their genomes follow the characteristic genome organization of all known arteriviruses, even though they are only distantly related to currently known rodent-borne arteriviruses. Phylogenetic analysis shows that Lopma virus clusters in the subfamily , while Praja virus clusters near members of the subfamily : the yet undescribed forest pouched giant rat arterivirus and hedgehog arterivirus 1. A co-divergence analysis of rodent-borne arteriviruses confirms that they share similar phylogenetic patterns with their hosts, with only very few cases of host shifting events throughout their evolutionary history. Overall, the genomes described here and their unique clustering with other arteriviruses further illustrate the existence of multiple rodent-borne arterivirus lineages, expanding our knowledge of the evolutionary origin of these viruses.
近年来，人们发现了几种属于动脉炎病毒科的新病毒，扩大了这组复杂 RNA 病毒的已知多样性和宿主范围。尽管这些新病毒的病理学相关性并不总是清楚，但已知该科的几个研究充分的成员是重要的动物病原体。在这里，我们报告了四种新动脉炎病毒变体的完整基因组序列，它们属于两个假定的新种。这些新的动脉炎病毒是在非洲啮齿动物中发现的，并被命名为 Lopma 病毒和 Praja 病毒。它们的基因组遵循所有已知动脉炎病毒的特征基因组组织，尽管它们与目前已知的啮齿动物携带的动脉炎病毒关系较远。系统发育分析表明，Lopma 病毒在亚科中聚类，而 Praja 病毒在亚科附近的成员聚类：尚未描述的森林袋巨鼠动脉炎病毒和刺猬动脉炎病毒 1。对啮齿动物携带的动脉炎病毒的共进化分析证实，它们与宿主具有相似的系统发育模式，在整个进化历史中只有极少数宿主转移事件。总体而言，这里描述的基因组及其与其他动脉炎病毒的独特聚类进一步说明了存在多种啮齿动物携带的动脉炎病毒谱系，扩展了我们对这些病毒进化起源的认识。
