Department of Physiology, Wayne State University, Detroit, MI 48201, USA.
Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
Nutrients. 2021 Sep 8;13(9):3129. doi: 10.3390/nu13093129.
Fructose and salt intake remain high, particularly in adolescents and young adults. The present studies were designed to evaluate the impact of high fructose and/or salt during pre- and early adolescence on salt sensitivity, blood pressure, arterial compliance, and left ventricular (LV) function in maturity. Male 5-week-old Sprague Dawley rats were studied over three 3-week phases (Phases I, II, and III). Two reference groups received either 20% glucose + 0.4% NaCl (GCS-GCS) or 20% fructose + 4% NaCl (FHS-FHS) throughout this study. The two test groups ingested fructose + 0.4% NaCl (FCS) or FHS during Phase I, then GCS in Phase II, and were then challenged with 20% glucose + 4% NaCl (GHS) in Phase III: FCS-GHS and FHS-GHS, respectively. Compared with GCS-GCS, systolic and mean pressures were significantly higher at the end of Phase III in all groups fed fructose during Phase I. Aortic pulse wave velocity (PWV) was elevated at the end of Phase I in FHS-GHS and FHS-FHS (vs. GCS-GCS). At the end of Phase III, PWV and renal resistive index were higher in FHS-GHS and FHS-FHS vs. GCS-GCS. Diastolic, but not systolic, LV function was impaired in the FHS-GHS and FHS-FHS but not FCS-FHS rats. Consumption of 20% fructose by male rats during adolescence results in salt-sensitive hypertension in maturity. When ingested with a high-salt diet during this early plastic phase, dietary fructose also predisposes to vascular stiffening and LV diastolic dysfunction in later life.
果糖和盐的摄入量仍然很高，尤其是在青少年和年轻人中。本研究旨在评估青春期前和早期摄入高果糖和/或盐对成熟时盐敏感性、血压、动脉顺应性和左心室（LV）功能的影响。雄性 5 周龄 Sprague Dawley 大鼠在三个 3 周阶段（阶段 I、II 和 III）进行研究。两个参考组在整个研究过程中分别接受 20%葡萄糖+0.4%NaCl（GCS-GCS）或 20%果糖+4%NaCl（FHS-FHS）。两个测试组在阶段 I 期间摄入果糖+0.4%NaCl（FCS）或 FHS，然后在阶段 II 期间摄入 GCS，然后在阶段 III 期间接受 20%葡萄糖+4%NaCl（GHS）挑战：FCS-GHS 和 FHS-GHS 分别。与 GCS-GCS 相比，所有在阶段 I 期间摄入果糖的组在阶段 III 结束时的收缩压和平均压均显着升高。在 FHS-GHS 和 FHS-FHS 中，主动脉脉搏波速度（PWV）在阶段 I 结束时升高（与 GCS-GCS 相比）。在阶段 III 结束时，FHS-GHS 和 FHS-FHS 的 PWV 和肾血管阻力指数均高于 GCS-GCS。FHS-GHS 和 FHS-FHS 大鼠的舒张期而不是收缩期 LV 功能受损，但 FCS-FHS 大鼠则没有。青春期雄性大鼠摄入 20%果糖可导致成熟时盐敏感性高血压。当在这个早期塑性阶段摄入高盐饮食时，饮食中的果糖也会导致血管僵硬和 LV 舒张功能障碍。
