Physiology and Internal Medicine, Nephrology and Hypertension, Wayne State University School of Medicine, Detroit, MI 48201, USA.
John D. Dingell VA Medical Center, Detroit, MI 48201, USA.
Nutrients. 2024 Mar 22;16(7):913. doi: 10.3390/nu16070913.
We aimed to investigate how dietary fructose and sodium impact blood pressure and risk of hypertensive target organ damage 10 years later. Data from = 3116 individuals were obtained from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Four groups were identified based on the four possible combinations of the lower and upper 50th percentile for sodium (in mg) and fructose (expressed as percent of total daily calories). Differences among groups were ascertained and logistic regression analyses were used to assess the risk of hypertensive target organ damage (diastolic dysfunction, coronary calcification and albuminuria). Individuals in the low-fructose + low-sodium group were found to have lower SBP compared to those in the low-fructose + high-sodium and high-fructose + high-sodium groups ( < 0.05). The highest risk for hypertensive target organ damage was found for albuminuria only in the high-fructose + high-sodium group (OR = 3.328, = 0.006) while female sex was protective across all groups against coronary calcification. Our findings highlight that sodium alone may not be the culprit for hypertension and hypertensive target organ damage, but rather when combined with an increased intake of dietary fructose, especially in middle-aged individuals.
我们旨在研究饮食中的果糖和钠对血压和 10 年后高血压靶器官损害风险的影响。研究数据来自于年轻人冠状动脉风险发展（CARDIA）研究中的 3116 个人。根据钠（mg）和果糖（以总日卡路里的百分比表示）的下 50%和上 50%的四个可能组合，确定了四个组。确定了各组之间的差异，并使用逻辑回归分析评估了高血压靶器官损害（舒张功能障碍、冠状动脉钙化和白蛋白尿）的风险。与低果糖+高钠组和高果糖+高钠组相比，低果糖+低钠组的收缩压较低（<0.05）。仅在高果糖+高钠组中，高血压靶器官损害的风险最高，仅见于白蛋白尿（OR=3.328，<0.006），而女性在所有组中均对冠状动脉钙化具有保护作用。我们的研究结果强调，仅钠可能不是高血压和高血压靶器官损害的罪魁祸首，而是当与饮食中果糖摄入量增加相结合时，尤其是在中年人群中。
