Baker J C, Jacobson M K
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2350-2. doi: 10.1073/pnas.83.8.2350.
Exposure of cultured mammalian cells to a variety of conditions that induce the synthesis of stress proteins, including hyperthermia, ethanol, cadmium, and arsenite resulted in an increased cellular content of adenyl dinucleotides including diadenosine tetraphosphate (Ap4A). Exposure to other agents that cause metabolic perturbations not known to induce the synthesis of stress proteins, such as cyclohexamide, cytosine arabinoside, hydroxyurea, and ultraviolet irradiation did not alter the content of these nucleotides. It is proposed that these unique nucleotides may mediate adaptive responses of mammalian cells to environmental stress.
将培养的哺乳动物细胞暴露于多种诱导应激蛋白合成的条件下，包括热疗、乙醇、镉和亚砷酸盐，导致细胞中腺苷二核苷酸的含量增加，包括四磷酸二腺苷（Ap4A）。暴露于其他引起代谢紊乱但未知诱导应激蛋白合成的试剂，如环己酰亚胺、阿糖胞苷、羟基脲和紫外线照射，并没有改变这些核苷酸的含量。有人提出，这些独特的核苷酸可能介导哺乳动物细胞对环境应激的适应性反应。
