Rachelefsky G S, Katz R M, Siegel S C
Ann Allergy. 1978 Apr;40(4):252-7.
In a double-blind, crossover study a sustained release theophylline preparation was found to be effective and safe while controlling the symptoms and improving the measured pulmonary function of 16 chronic childhood asthmatics. Serum theophylline levels between 2.5 and 8.1 microgram/ml were adequate for control of clinical disease.
在一项双盲交叉研究中,发现一种缓释茶碱制剂在控制16名儿童慢性哮喘患者的症状并改善其测定的肺功能方面有效且安全。血清茶碱水平在2.5至8.1微克/毫升之间足以控制临床疾病。