Department of Family Medicine, Wroclaw Medical University, Wroclaw, Poland.
Department of Pharmacognosy and Herbal Medicines, Wroclaw Medical University, Wroclaw, Poland.
Int J Public Health. 2021 Jul 30;66:1603975. doi: 10.3389/ijph.2021.1603975. eCollection 2021.
The aim of this review is to summarize the most relevant scientific discoveries regarding SARS- CoV-2 virus infection, with the special emphasis put on its pathophysiology and way of treatment. In November 2020, the research articles have been collected and examined manually to pick the most relevant. In case of fresh topics, e.g. vaccines, we have performed searching using adequate keywords. Preliminary analysis was conducted on 200 manuscripts. Among them 59 papers were out-of-scope, and thus were rejected from the further elaboration. Another 25 papers were rebuffed because they presented topics, that have been extensively described in the already included papers. Basing on the 29 papers we have estimated ratio of observed SARS-CoV-2 infection clinical manifestations and comorbidities among hospitalized patients. 12 papers let us evaluate frequencies of deviations within laboratory markers concentrations, as well as weighted average of the laboratory tests results. Due to the significant infectivity of the virus and its harmfulness towards organism further studies are required to find accurate way of the disease treatment and suspending its spreading.
本文旨在总结与 SARS-CoV-2 病毒感染相关的最重要的科学发现，特别强调其病理生理学和治疗方法。2020 年 11 月，我们通过手动收集和检查研究文章，以挑选出最相关的文章。对于新的主题，例如疫苗，我们使用了适当的关键字进行搜索。我们对 200 篇手稿进行了初步分析。其中 59 篇文章不在研究范围内，因此被排除在进一步阐述之外。另外 25 篇文章被拒绝，因为它们所提出的主题已经在已包含的文章中进行了广泛描述。基于这 29 篇文章，我们评估了住院患者中观察到的 SARS-CoV-2 感染临床表现和合并症的比例。有 12 篇文章让我们评估了实验室标志物浓度内偏差的频率，以及实验室检测结果的加权平均值。由于该病毒的高传染性及其对机体的危害性，需要进一步研究以找到准确的疾病治疗方法并阻止其传播。
